Medium-term effectiveness of L-thyroxine treatment in idiopathic dilated cardiomyopathy

Paolo Moruzzi, Elisabetta Doria, Pier Giuseppe Agostoni

Research output: Contribution to journalArticlepeer-review

Abstract

BACKGROUND: In dilated cardiomyopathy, short-term administration of L-thyroxine (100 μg/ day) improves cardiac and exercise performance without changing the heart's adrenergic sensitivity. The aim of this study was to test the medium-term (3 months) efficacy of L-thyroxine (10 patients) compared with placebo (10 patients) and to find out whether later effects are obtainable. METHODS: Echocardiographic parameters in the control state and during acute changes of left ventricular after load, cardiopulmonary exercise test, and hemodynamic parameters, including cardiac β1 responses to dobutamine, were obtained before and at the end of treatment. RESULTS: Significant (P

Original languageEnglish
Pages (from-to)461-467
Number of pages7
JournalAmerican Journal of Medicine
Volume101
Issue number5
DOIs
Publication statusPublished - Nov 1996

ASJC Scopus subject areas

  • Nursing(all)

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