Medullary breast carcinoma in an 18-year-old female: Report on one case diagnosed on fine-needle cytology sample

Antonio Galzerano, Nicola Rocco, Antonello Accurso, Giuseppe Ciancia, Anna Cipolletta Campanile, Ferdinando Caccavello, Franco Fulciniti

Research output: Contribution to journalArticle

Abstract

Medullary breast carcinoma (MBC) is a rare epithelial malignancy of the breast accounting for about 1-7% of all breast carcinomas. It is characterized by well-defined borders, a syncytial/solid pattern of growth of high grade atypical cells showing no glandular differentiation and a massive diffuse lympho-plasmacytic peritumoral infiltrate. Despite the high-grade atypias characterizing this neoplasm, MBC has been reported to have a better prognosis when compared with the common infiltrating duct carcinoma. MBCs typically lack estrogen and progesterone receptor (ER and PgR) expression and have a low incidence of ERBB2 overexpression. Genetically, they are often associated with BRCA-1 oncogene mutations and TP53 alterations. While MBC generally occurs in middle-aged women, ranging from 45 to 52 years of age, we report the case of a 18-year-old female patient which was diagnosed by means of fine-needle cytology sample. Diagn. Cytopathol. 2014;42:445-448. © 2013 Wiley Periodicals, Inc.

Original languageEnglish
Pages (from-to)445-448
Number of pages4
JournalDiagnostic Cytopathology
Volume42
Issue number5
DOIs
Publication statusPublished - 2014

Keywords

  • breast neoplasms
  • fine-needle cytology
  • juvenile breast carcinoma
  • medullary breast carcinoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology
  • Medicine(all)

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    Galzerano, A., Rocco, N., Accurso, A., Ciancia, G., Campanile, A. C., Caccavello, F., & Fulciniti, F. (2014). Medullary breast carcinoma in an 18-year-old female: Report on one case diagnosed on fine-needle cytology sample. Diagnostic Cytopathology, 42(5), 445-448. https://doi.org/10.1002/dc.22947