Meet me in the cytoplasm: A role for p27Kip1 in the control of H-Ras

Research output: Contribution to journalComment/debate

Abstract

The small GTPases of the Ras family play a pivotal role in the regulation of cell proliferation and motility, both in normal and transformed cells. In particular, the 3 genes encoding for the N-, H- and K-Ras are frequently mutated in human cancer and their inappropriate regulation, expression and subcellular localization can drive tumor onset and progression. Activation of the Ras-MAPK pathway directly signals on the cell cycle machinery by regulating the expression and/or localization of 2 key cell cycle player, Cyclin D1 and p27Kip1. We recently reported that in normal fibroblasts, following mitogenic stimuli, p27Kip1 translocates to the cytoplasm where it regulates H-Ras localization and activity. This regulatory mechanism ensures that cells pass beyond the restriction point of the cell cycle only when the proper level of stimulation is reached. Here, we comment on this new evidence that possibly represents one of the ways that cells have developed during evolution to ensure that the cell decision to divide is taken only when time and context are appropriate.

Original languageEnglish
Pages (from-to)71-75
Number of pages5
JournalSmall GTPases
Volume7
Issue number2
DOIs
Publication statusPublished - Apr 2 2016

Keywords

  • cell cycle
  • H-Ras
  • K-Ras
  • microtubule stability
  • motility
  • p27kip
  • proliferation
  • stathmin

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology

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