MEF promotes stemness in the pathogenesis of gliomas

Elena Bazzoli; Teodoro Pulvirenti; Moritz C. Oberstadt; Fabiana Perna; Boyoung Wee; Nikolaus Schultz; Jason T. Huse; Elena I. Fomchenko; Francesca Voza; Viviane Tabar; Cameron W. Brennan; Lisa M. Deangelis; Stephen D. Nimer; Eric C. Holland; Massimo Squatrito

doi:10.1016/j.stem.2012.09.012

MEF promotes stemness in the pathogenesis of gliomas

Elena Bazzoli, Teodoro Pulvirenti, Moritz C. Oberstadt, Fabiana Perna, Boyoung Wee, Nikolaus Schultz, Jason T. Huse, Elena I. Fomchenko, Francesca Voza, Viviane Tabar, Cameron W. Brennan, Lisa M. Deangelis, Stephen D. Nimer, Eric C. Holland, Massimo Squatrito

Centro San Giovanni di Dio - Fatebenefratelli

Research output: Contribution to journal › Article › peer-review

Abstract

High-grade gliomas are aggressive and uniformly fatal tumors, composed of a heterogeneous population of cells that include many with stem-cell-like properties. The acquisition of stem-like traits might contribute to glioma initiation, growth, and recurrence. Here we investigated the role of the transcription factor myeloid Elf-1 like factor (MEF, also known as ELF4) in gliomas. We found that MEF is highly expressed in both human and mouse glioblastomas and its absence impairs gliomagenesis in a PDGF-driven glioma mouse model. We show that modulation of MEF levels in both mouse neural stem cells and human glioblastoma cells has a significant impact on neurosphere formation. Moreover, we identify Sox2 as a direct downstream target of MEF. Taken together, our studies implicate MEF as a previously unrecognized gatekeeper gene in gliomagenesis that promotes stem cell characteristics through Sox2 activation.

Original language	English
Pages (from-to)	836-844
Number of pages	9
Journal	Cell Stem Cell
Volume	11
Issue number	6
DOIs	https://doi.org/10.1016/j.stem.2012.09.012
Publication status	Published - Dec 7 2012

ASJC Scopus subject areas

Cell Biology
Molecular Medicine
Genetics

Access to Document

10.1016/j.stem.2012.09.012

Fingerprint Dive into the research topics of 'MEF promotes stemness in the pathogenesis of gliomas'. Together they form a unique fingerprint.

Cite this

MEF promotes stemness in the pathogenesis of gliomas. / Bazzoli, Elena; Pulvirenti, Teodoro; Oberstadt, Moritz C.; Perna, Fabiana; Wee, Boyoung; Schultz, Nikolaus; Huse, Jason T.; Fomchenko, Elena I.; Voza, Francesca; Tabar, Viviane; Brennan, Cameron W.; Deangelis, Lisa M.; Nimer, Stephen D.; Holland, Eric C.; Squatrito, Massimo.

In: Cell Stem Cell, Vol. 11, No. 6, 07.12.2012, p. 836-844.

Research output: Contribution to journal › Article › peer-review

Bazzoli, Elena ; Pulvirenti, Teodoro ; Oberstadt, Moritz C. ; Perna, Fabiana ; Wee, Boyoung ; Schultz, Nikolaus ; Huse, Jason T. ; Fomchenko, Elena I. ; Voza, Francesca ; Tabar, Viviane ; Brennan, Cameron W. ; Deangelis, Lisa M. ; Nimer, Stephen D. ; Holland, Eric C. ; Squatrito, Massimo. / MEF promotes stemness in the pathogenesis of gliomas. In: Cell Stem Cell. 2012 ; Vol. 11, No. 6. pp. 836-844.

@article{75fcd82e5da94141aba986508ea91a60,

title = "MEF promotes stemness in the pathogenesis of gliomas",

abstract = "High-grade gliomas are aggressive and uniformly fatal tumors, composed of a heterogeneous population of cells that include many with stem-cell-like properties. The acquisition of stem-like traits might contribute to glioma initiation, growth, and recurrence. Here we investigated the role of the transcription factor myeloid Elf-1 like factor (MEF, also known as ELF4) in gliomas. We found that MEF is highly expressed in both human and mouse glioblastomas and its absence impairs gliomagenesis in a PDGF-driven glioma mouse model. We show that modulation of MEF levels in both mouse neural stem cells and human glioblastoma cells has a significant impact on neurosphere formation. Moreover, we identify Sox2 as a direct downstream target of MEF. Taken together, our studies implicate MEF as a previously unrecognized gatekeeper gene in gliomagenesis that promotes stem cell characteristics through Sox2 activation.",

author = "Elena Bazzoli and Teodoro Pulvirenti and Oberstadt, {Moritz C.} and Fabiana Perna and Boyoung Wee and Nikolaus Schultz and Huse, {Jason T.} and Fomchenko, {Elena I.} and Francesca Voza and Viviane Tabar and Brennan, {Cameron W.} and Deangelis, {Lisa M.} and Nimer, {Stephen D.} and Holland, {Eric C.} and Massimo Squatrito",

year = "2012",

month = dec,

day = "7",

doi = "10.1016/j.stem.2012.09.012",

language = "English",

volume = "11",

pages = "836--844",

journal = "Cell Stem Cell",

issn = "1934-5909",

publisher = "Cell Press",

number = "6",

}

TY - JOUR

T1 - MEF promotes stemness in the pathogenesis of gliomas

AU - Bazzoli, Elena

AU - Pulvirenti, Teodoro

AU - Oberstadt, Moritz C.

AU - Perna, Fabiana

AU - Wee, Boyoung

AU - Schultz, Nikolaus

AU - Huse, Jason T.

AU - Fomchenko, Elena I.

AU - Voza, Francesca

AU - Tabar, Viviane

AU - Brennan, Cameron W.

AU - Deangelis, Lisa M.

AU - Nimer, Stephen D.

AU - Holland, Eric C.

AU - Squatrito, Massimo

PY - 2012/12/7

Y1 - 2012/12/7

N2 - High-grade gliomas are aggressive and uniformly fatal tumors, composed of a heterogeneous population of cells that include many with stem-cell-like properties. The acquisition of stem-like traits might contribute to glioma initiation, growth, and recurrence. Here we investigated the role of the transcription factor myeloid Elf-1 like factor (MEF, also known as ELF4) in gliomas. We found that MEF is highly expressed in both human and mouse glioblastomas and its absence impairs gliomagenesis in a PDGF-driven glioma mouse model. We show that modulation of MEF levels in both mouse neural stem cells and human glioblastoma cells has a significant impact on neurosphere formation. Moreover, we identify Sox2 as a direct downstream target of MEF. Taken together, our studies implicate MEF as a previously unrecognized gatekeeper gene in gliomagenesis that promotes stem cell characteristics through Sox2 activation.

AB - High-grade gliomas are aggressive and uniformly fatal tumors, composed of a heterogeneous population of cells that include many with stem-cell-like properties. The acquisition of stem-like traits might contribute to glioma initiation, growth, and recurrence. Here we investigated the role of the transcription factor myeloid Elf-1 like factor (MEF, also known as ELF4) in gliomas. We found that MEF is highly expressed in both human and mouse glioblastomas and its absence impairs gliomagenesis in a PDGF-driven glioma mouse model. We show that modulation of MEF levels in both mouse neural stem cells and human glioblastoma cells has a significant impact on neurosphere formation. Moreover, we identify Sox2 as a direct downstream target of MEF. Taken together, our studies implicate MEF as a previously unrecognized gatekeeper gene in gliomagenesis that promotes stem cell characteristics through Sox2 activation.

UR - http://www.scopus.com/inward/record.url?scp=84870871140&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84870871140&partnerID=8YFLogxK

U2 - 10.1016/j.stem.2012.09.012

DO - 10.1016/j.stem.2012.09.012

M3 - Article

C2 - 23217424

AN - SCOPUS:84870871140

VL - 11

SP - 836

EP - 844

JO - Cell Stem Cell

JF - Cell Stem Cell

SN - 1934-5909

IS - 6

ER -

MEF promotes stemness in the pathogenesis of gliomas

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Cite this