Megaduodenum: An unusual presentation of amyloidosis?

L. Elli, G. Falconieri, M. T. Bardella, M. Caldato, S. Pizzolitto, A. Bonura, M. Zilli, R. Maieron

Research output: Contribution to journalArticle

Abstract

Amyloidosis, a potentially fatal disease, is characterized by an abnormal deposition of autologous proteins. Heart, liver, kidneys, lung, thyroid, skin and the gastrointestinal tract can be involved; in this last case mucosal alterations or disturbances of the motility leading to pseudo-obstruction, bleeding, diarrhea and malabsorption can be present. However, the data concerning the possible gastrointestinal presentations of amyloidosis are scanty and heterogeneous. We report the case of a patient presenting severe gastrointestinal symptoms caused by a megaduodenum. The patient was thoroughly investigated and lesions appeared limited to the upper gastrointestinal tract in the absence of a systemic disorder. However, at follow up the patient developed cardiac dilatation and bioptic samples revealed the presence of amyloidosis.

Original languageEnglish
Pages (from-to)287-291
Number of pages5
JournalActa Gastro-Enterologica Belgica
Volume73
Issue number2
Publication statusPublished - Apr 2010

Keywords

  • Amyloidosis
  • Endoscopy
  • Megaduodenum
  • Neuroendocrine cells

ASJC Scopus subject areas

  • Gastroenterology

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    Elli, L., Falconieri, G., Bardella, M. T., Caldato, M., Pizzolitto, S., Bonura, A., Zilli, M., & Maieron, R. (2010). Megaduodenum: An unusual presentation of amyloidosis? Acta Gastro-Enterologica Belgica, 73(2), 287-291.