Megakaryocyte contribution to bone marrow fibrosis: Many arrows in the quiver

Alessandro Malara, Vittorio Abbonante, Maria Zingariello, Annarita Migliaccio, Alessandra Balduini

Research output: Contribution to journalArticlepeer-review

Abstract

In Primary Myelofibrosis (PMF), megakaryocyte dysplasia/hyperplasia determines the release of inflammatory cytokines that, in turn, stimulate stromal cells and induce bone marrow fibrosis. The pathogenic mechanism and the cells responsible for progression to bone marrow fibrosis in PMF are not completely understood. This review article aims to provide an overview of the crucial role of megakaryocytes in myelofibrosis by discussing the role and the altered secretion of megakaryocyte-derived soluble factors, enzymes and extracellular matrices that are known to induce bone marrow fibrosis.

Original languageEnglish
Article numbere2018068
JournalMediterranean Journal of Hematology and Infectious Diseases
Volume10
Issue number1
DOIs
Publication statusPublished - Jan 1 2018

Keywords

  • Bone marrow
  • Fibrosis
  • Megakaryocyte
  • Myeloproliferative neoplasms
  • Platelets
  • Transforming growth factor-

ASJC Scopus subject areas

  • Hematology
  • Infectious Diseases

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