TY - JOUR
T1 - Megakaryocyte contribution to bone marrow fibrosis
T2 - Many arrows in the quiver
AU - Malara, Alessandro
AU - Abbonante, Vittorio
AU - Zingariello, Maria
AU - Migliaccio, Annarita
AU - Balduini, Alessandra
PY - 2018/1/1
Y1 - 2018/1/1
N2 - In Primary Myelofibrosis (PMF), megakaryocyte dysplasia/hyperplasia determines the release of inflammatory cytokines that, in turn, stimulate stromal cells and induce bone marrow fibrosis. The pathogenic mechanism and the cells responsible for progression to bone marrow fibrosis in PMF are not completely understood. This review article aims to provide an overview of the crucial role of megakaryocytes in myelofibrosis by discussing the role and the altered secretion of megakaryocyte-derived soluble factors, enzymes and extracellular matrices that are known to induce bone marrow fibrosis.
AB - In Primary Myelofibrosis (PMF), megakaryocyte dysplasia/hyperplasia determines the release of inflammatory cytokines that, in turn, stimulate stromal cells and induce bone marrow fibrosis. The pathogenic mechanism and the cells responsible for progression to bone marrow fibrosis in PMF are not completely understood. This review article aims to provide an overview of the crucial role of megakaryocytes in myelofibrosis by discussing the role and the altered secretion of megakaryocyte-derived soluble factors, enzymes and extracellular matrices that are known to induce bone marrow fibrosis.
KW - Bone marrow
KW - Fibrosis
KW - Megakaryocyte
KW - Myeloproliferative neoplasms
KW - Platelets
KW - Transforming growth factor-
UR - http://www.scopus.com/inward/record.url?scp=85057630086&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85057630086&partnerID=8YFLogxK
U2 - 10.4084/MJHID.2018.068
DO - 10.4084/MJHID.2018.068
M3 - Article
AN - SCOPUS:85057630086
VL - 10
JO - Mediterranean Journal of Hematology and Infectious Diseases
JF - Mediterranean Journal of Hematology and Infectious Diseases
SN - 2035-3006
IS - 1
M1 - e2018068
ER -