Megakaryocytes in Bone Metastasis: Protection or Progression?

Paola Maroni

Research output: Contribution to journalReview article

Abstract

Bone is the primary site where some cancers develop secondary growth, particularly those derived from breast and prostate tissue. The spread of metastasis to distant sites relies on complex mechanisms by which only cells endowed with certain characteristics are able to reach secondary growth sites. Platelets play a pivotal role in tumour growth, by conferring resistance to shear stress to the circulating tumour cells and protection against natural killer cell attack. Mature polyploid megakaryocytes (MKs) reside in close proximity to the vascular sinusoids of bone marrow, where their primary function is to produce platelets. Emerging evidence has demonstrated that MKs are essential for skeletal homeostasis, due to the expression and production of the bone-related proteins osteocalcin, osteonectin, bone morphogenetic protein, osteopontin, bone sialoprotein, and osteoprotegerin. Debate surrounds the role that MKs play in the development of bone metastasis, which is the topic of this mini-review.

Original languageEnglish
JournalCells
Volume8
Issue number2
DOIs
Publication statusPublished - Feb 8 2019

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Megakaryocytes
Bone
Neoplasm Metastasis
Bone and Bones
Blood Platelets
Growth
Platelets
Osteonectin
Integrin-Binding Sialoprotein
Circulating Neoplastic Cells
Osteoprotegerin
Tumors
Bone Morphogenetic Proteins
Osteopontin
Polyploidy
Cytoprotection
Bone Development
Osteocalcin
Natural Killer Cells
Blood Vessels

Cite this

Megakaryocytes in Bone Metastasis : Protection or Progression? / Maroni, Paola.

In: Cells, Vol. 8, No. 2, 08.02.2019.

Research output: Contribution to journalReview article

Maroni, Paola. / Megakaryocytes in Bone Metastasis : Protection or Progression?. In: Cells. 2019 ; Vol. 8, No. 2.
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AB - Bone is the primary site where some cancers develop secondary growth, particularly those derived from breast and prostate tissue. The spread of metastasis to distant sites relies on complex mechanisms by which only cells endowed with certain characteristics are able to reach secondary growth sites. Platelets play a pivotal role in tumour growth, by conferring resistance to shear stress to the circulating tumour cells and protection against natural killer cell attack. Mature polyploid megakaryocytes (MKs) reside in close proximity to the vascular sinusoids of bone marrow, where their primary function is to produce platelets. Emerging evidence has demonstrated that MKs are essential for skeletal homeostasis, due to the expression and production of the bone-related proteins osteocalcin, osteonectin, bone morphogenetic protein, osteopontin, bone sialoprotein, and osteoprotegerin. Debate surrounds the role that MKs play in the development of bone metastasis, which is the topic of this mini-review.

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