Melanocyte-specific, cytotoxic T cell responses in vitiligo: The effective variant of melanoma immunity?

Silvia Garbelli, Stefania Mantovani, Belinda Palermo, Claudia Giachino

Research output: Contribution to journalReview article

38 Citations (Scopus)

Abstract

Vitiligo is a relatively common progressive depigmentary condition that is believed to be due to the autoimmune-mediated loss of epidermal melanocytes. An interesting aspect of vitiligo is its relation to melanoma: cytotoxic T lymphocytes directed to self-antigens shared by normal melanocytes and melanoma cells are found in both conditions and might prove important in melanocyte destruction, yet the resulting immune reactions are completely different. From this standpoint, the selective destruction of pigment cells that occurs in cases of vitiligo is the therapeutic goal sought in melanoma research. In the present article, we will address these issues by reviewing current literature on the subject as well as by posing some speculations.

Original languageEnglish
Pages (from-to)234-242
Number of pages9
JournalPigment Cell Research
Volume18
Issue number4
DOIs
Publication statusPublished - Aug 2005

Fingerprint

Antigen-antibody reactions
Vitiligo
T-cells
melanocytes
Melanocytes
Autoantigens
melanoma
Pigments
Immunity
Melanoma
T-lymphocytes
immunity
T-Lymphocytes
cytotoxic T-lymphocytes
Cytotoxic T-Lymphocytes
pigments
cells
antigens
therapeutics
Research

Keywords

  • Autoimmunity
  • Cytotoxic T cells
  • Melanocyte antigens
  • Tumor immunity

ASJC Scopus subject areas

  • Cell Biology
  • Agronomy and Crop Science
  • Plant Science
  • Clinical Biochemistry
  • Developmental Biology

Cite this

Melanocyte-specific, cytotoxic T cell responses in vitiligo : The effective variant of melanoma immunity? / Garbelli, Silvia; Mantovani, Stefania; Palermo, Belinda; Giachino, Claudia.

In: Pigment Cell Research, Vol. 18, No. 4, 08.2005, p. 234-242.

Research output: Contribution to journalReview article

Garbelli, Silvia ; Mantovani, Stefania ; Palermo, Belinda ; Giachino, Claudia. / Melanocyte-specific, cytotoxic T cell responses in vitiligo : The effective variant of melanoma immunity?. In: Pigment Cell Research. 2005 ; Vol. 18, No. 4. pp. 234-242.
@article{d099129af2df4bcd97a009b0f2bc4cda,
title = "Melanocyte-specific, cytotoxic T cell responses in vitiligo: The effective variant of melanoma immunity?",
abstract = "Vitiligo is a relatively common progressive depigmentary condition that is believed to be due to the autoimmune-mediated loss of epidermal melanocytes. An interesting aspect of vitiligo is its relation to melanoma: cytotoxic T lymphocytes directed to self-antigens shared by normal melanocytes and melanoma cells are found in both conditions and might prove important in melanocyte destruction, yet the resulting immune reactions are completely different. From this standpoint, the selective destruction of pigment cells that occurs in cases of vitiligo is the therapeutic goal sought in melanoma research. In the present article, we will address these issues by reviewing current literature on the subject as well as by posing some speculations.",
keywords = "Autoimmunity, Cytotoxic T cells, Melanocyte antigens, Tumor immunity",
author = "Silvia Garbelli and Stefania Mantovani and Belinda Palermo and Claudia Giachino",
year = "2005",
month = "8",
doi = "10.1111/j.1600-0749.2005.00244.x",
language = "English",
volume = "18",
pages = "234--242",
journal = "Pigment Cell Research",
issn = "0893-5785",
publisher = "Wiley-Blackwell",
number = "4",

}

TY - JOUR

T1 - Melanocyte-specific, cytotoxic T cell responses in vitiligo

T2 - The effective variant of melanoma immunity?

AU - Garbelli, Silvia

AU - Mantovani, Stefania

AU - Palermo, Belinda

AU - Giachino, Claudia

PY - 2005/8

Y1 - 2005/8

N2 - Vitiligo is a relatively common progressive depigmentary condition that is believed to be due to the autoimmune-mediated loss of epidermal melanocytes. An interesting aspect of vitiligo is its relation to melanoma: cytotoxic T lymphocytes directed to self-antigens shared by normal melanocytes and melanoma cells are found in both conditions and might prove important in melanocyte destruction, yet the resulting immune reactions are completely different. From this standpoint, the selective destruction of pigment cells that occurs in cases of vitiligo is the therapeutic goal sought in melanoma research. In the present article, we will address these issues by reviewing current literature on the subject as well as by posing some speculations.

AB - Vitiligo is a relatively common progressive depigmentary condition that is believed to be due to the autoimmune-mediated loss of epidermal melanocytes. An interesting aspect of vitiligo is its relation to melanoma: cytotoxic T lymphocytes directed to self-antigens shared by normal melanocytes and melanoma cells are found in both conditions and might prove important in melanocyte destruction, yet the resulting immune reactions are completely different. From this standpoint, the selective destruction of pigment cells that occurs in cases of vitiligo is the therapeutic goal sought in melanoma research. In the present article, we will address these issues by reviewing current literature on the subject as well as by posing some speculations.

KW - Autoimmunity

KW - Cytotoxic T cells

KW - Melanocyte antigens

KW - Tumor immunity

UR - http://www.scopus.com/inward/record.url?scp=22744451812&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=22744451812&partnerID=8YFLogxK

U2 - 10.1111/j.1600-0749.2005.00244.x

DO - 10.1111/j.1600-0749.2005.00244.x

M3 - Review article

C2 - 16029417

AN - SCOPUS:22744451812

VL - 18

SP - 234

EP - 242

JO - Pigment Cell Research

JF - Pigment Cell Research

SN - 0893-5785

IS - 4

ER -