Melasma, a photoaging disorder

Thierry Passeron, Mauro Picardo

Research output: Contribution to journalReview articlepeer-review


Melasma is a common hyperpigmentary disorder. The impact on the quality of life of affected individuals is well demonstrated, demanding new therapeutic strategies. However, the treatment of melasma remains highly challenging. Melasma is often considered as the main consequence of female hormone stimulation on a predisposed genetic background. Although these two factors do contribute to this acquired pigmentary disorder, the last decade has revealed several other key players and brought new pieces to the complex puzzle of the pathophysiology of melasma. Here, we summarize the latest evidence on the pathophysiology of melasma, and we suggest that melasma might be a photoaging skin disorder affecting genetically predisposed individuals. Such data must be taken into consideration by clinicians as they could have a profound impact on the treatment and the prevention of melasma.

Original languageEnglish
Pages (from-to)461-465
Number of pages5
JournalPigment Cell and Melanoma Research
Issue number4
Publication statusPublished - Jul 2018


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