Abstract
Melatonin (MEL) may counteract tumors through a direct oncostatic role. MEL is also an antistress agent with immunoenhancing properties against tumors due to a suppressive role of MEL on corticosterone release. Rotational stress (RS) (spatial disorientation) facilitates metastasis progression in mice. Also, MEL counteracts tumors because of its influence on immune responses via the metabolic zinc pool, which, is reduced in tumors and stress. Zinc is required for normal thymic endocrine activity (i.e. thymulin) and interleukin-2 (IL-2) production. Because in vivo data is still controversial, exogenous MEL treatment (22 days in drinking water) in both intact and pinealectomized (px) mice bearing Lewis lung carcinoma leads to significant decrements of metastasis volume, restoration of the negative crude zinc balance, recovery of thymulin activity and increment of IL-2 exclusively in intact and px tumor bearing mice subjected to RS. Significant inverse correlations are found in both stressed intact and px tumor bearing mice after MEL treatment between zinc and corticosterone (r = 0.78, P <0.01; r = 0.80, P <0.01, respectively). Positive correlations between zinc and IL-2 (r = 0.75, P <0.01; r = 0.73, P <0.01, respectively) or thymulin (r = 0.75, P <0.01; r = 0.82, P <0.01, respectively) are observed in same models of mice. These findings suggest a MEL action to decrease metastasis mediated by a possible interplay between zinc and MEL, via corticosterone, with consequent restoration of thymic efficiency and IL-2 production. MEL as an antistress agent with immunoenhancing properties in cancer deserves further consideration. Copyright (C) 1999 Elsevier Science B.V.
| Original language | English |
|---|---|
| Pages (from-to) | 27-46 |
| Number of pages | 20 |
| Journal | International Journal of Immunopharmacology |
| Volume | 21 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jan 25 1999 |
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Keywords
- Corticosterone
- IL-2
- Melatonin
- Metastasis
- Stress
- Thymulin
- Zinc
ASJC Scopus subject areas
- Immunology
- Pharmacology
Cite this
Melatonin administration in tumor-bearing mice (intact and pinealectomized) in relation to stress, zinc, thymulin and IL-2. / Mocchegiani, E.; Perissin, L.; Santarelli, L.; Tibaldi, A.; Zorzet, S.; Rapozzi, V.; Giacconi, R.; Bulian, D.; Giraldi, T.
In: International Journal of Immunopharmacology, Vol. 21, No. 1, 25.01.1999, p. 27-46.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Melatonin administration in tumor-bearing mice (intact and pinealectomized) in relation to stress, zinc, thymulin and IL-2
AU - Mocchegiani, E.
AU - Perissin, L.
AU - Santarelli, L.
AU - Tibaldi, A.
AU - Zorzet, S.
AU - Rapozzi, V.
AU - Giacconi, R.
AU - Bulian, D.
AU - Giraldi, T.
PY - 1999/1/25
Y1 - 1999/1/25
N2 - Melatonin (MEL) may counteract tumors through a direct oncostatic role. MEL is also an antistress agent with immunoenhancing properties against tumors due to a suppressive role of MEL on corticosterone release. Rotational stress (RS) (spatial disorientation) facilitates metastasis progression in mice. Also, MEL counteracts tumors because of its influence on immune responses via the metabolic zinc pool, which, is reduced in tumors and stress. Zinc is required for normal thymic endocrine activity (i.e. thymulin) and interleukin-2 (IL-2) production. Because in vivo data is still controversial, exogenous MEL treatment (22 days in drinking water) in both intact and pinealectomized (px) mice bearing Lewis lung carcinoma leads to significant decrements of metastasis volume, restoration of the negative crude zinc balance, recovery of thymulin activity and increment of IL-2 exclusively in intact and px tumor bearing mice subjected to RS. Significant inverse correlations are found in both stressed intact and px tumor bearing mice after MEL treatment between zinc and corticosterone (r = 0.78, P <0.01; r = 0.80, P <0.01, respectively). Positive correlations between zinc and IL-2 (r = 0.75, P <0.01; r = 0.73, P <0.01, respectively) or thymulin (r = 0.75, P <0.01; r = 0.82, P <0.01, respectively) are observed in same models of mice. These findings suggest a MEL action to decrease metastasis mediated by a possible interplay between zinc and MEL, via corticosterone, with consequent restoration of thymic efficiency and IL-2 production. MEL as an antistress agent with immunoenhancing properties in cancer deserves further consideration. Copyright (C) 1999 Elsevier Science B.V.
AB - Melatonin (MEL) may counteract tumors through a direct oncostatic role. MEL is also an antistress agent with immunoenhancing properties against tumors due to a suppressive role of MEL on corticosterone release. Rotational stress (RS) (spatial disorientation) facilitates metastasis progression in mice. Also, MEL counteracts tumors because of its influence on immune responses via the metabolic zinc pool, which, is reduced in tumors and stress. Zinc is required for normal thymic endocrine activity (i.e. thymulin) and interleukin-2 (IL-2) production. Because in vivo data is still controversial, exogenous MEL treatment (22 days in drinking water) in both intact and pinealectomized (px) mice bearing Lewis lung carcinoma leads to significant decrements of metastasis volume, restoration of the negative crude zinc balance, recovery of thymulin activity and increment of IL-2 exclusively in intact and px tumor bearing mice subjected to RS. Significant inverse correlations are found in both stressed intact and px tumor bearing mice after MEL treatment between zinc and corticosterone (r = 0.78, P <0.01; r = 0.80, P <0.01, respectively). Positive correlations between zinc and IL-2 (r = 0.75, P <0.01; r = 0.73, P <0.01, respectively) or thymulin (r = 0.75, P <0.01; r = 0.82, P <0.01, respectively) are observed in same models of mice. These findings suggest a MEL action to decrease metastasis mediated by a possible interplay between zinc and MEL, via corticosterone, with consequent restoration of thymic efficiency and IL-2 production. MEL as an antistress agent with immunoenhancing properties in cancer deserves further consideration. Copyright (C) 1999 Elsevier Science B.V.
KW - Corticosterone
KW - IL-2
KW - Melatonin
KW - Metastasis
KW - Stress
KW - Thymulin
KW - Zinc
UR - http://www.scopus.com/inward/record.url?scp=0033012735&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033012735&partnerID=8YFLogxK
U2 - 10.1016/S0192-0561(98)00067-8
DO - 10.1016/S0192-0561(98)00067-8
M3 - Article
C2 - 10411280
AN - SCOPUS:0033012735
VL - 21
SP - 27
EP - 46
JO - International Journal of Immunopharmacology
JF - International Journal of Immunopharmacology
SN - 0192-0561
IS - 1
ER -