Melatonin and cortisol serum levels in lung cancer patients at different stages of disease

Gianluigi Mazzoccoli, Stefano Carughi, Angelo De Cata, Marco La Viola, Gianluigi Vendemiale

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Background: Numerous interactions exist among the nervous, endocrine, and immune systems, mediated by neurotransmitters, hormones, and cytokines. Melatonin may modulate the integrated functions of a unique neuro-immune- endocrine system. Neoplastic diseases may be linked to progressive loss of integration among these systems. We investigated whether there are differences among healthy elderly people and elderly people suffering from lung cancer at different stages of disease in 24-hour melatonin and cortisol secretory profiles. Material/Methods: In seventeen healthy subjects (mean age ±S.E.: 68.8±1.92 years), seventeen patients with stage I and II lung cancer (mean age: 67.2±0.80), seventeen patients with stage III and IV lung cancer (mean age: 69.5±2.26), melatonin and cortisol serum levels were measured in blood samples collected every four hours for 24 hours. The area under the curve (AUC) and the presence of circadian rhythmicity were evaluated. Results: The circadian rhythm of melatonin was present in all the groups, but serum levels were decreased in the subjects suffering from lung cancer (P

Original languageEnglish
JournalMedical Science Monitor
Volume11
Issue number6
Publication statusPublished - Jun 2005

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Melatonin
Hydrocortisone
Lung Neoplasms
Endocrine System
Serum
Immune System
Systems Integration
Periodicity
Circadian Rhythm
Nervous System
Area Under Curve
Neurotransmitter Agents
Healthy Volunteers
Hormones
Cytokines

Keywords

  • Circadian rhythm
  • Cortisol
  • Lung cancer
  • Melatonin
  • Neuroimmunendocrine system

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Melatonin and cortisol serum levels in lung cancer patients at different stages of disease. / Mazzoccoli, Gianluigi; Carughi, Stefano; De Cata, Angelo; La Viola, Marco; Vendemiale, Gianluigi.

In: Medical Science Monitor, Vol. 11, No. 6, 06.2005.

Research output: Contribution to journalArticle

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AU - Vendemiale, Gianluigi

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