Melatonin and delayed sleep phase syndrome: Ambulatory polygraphic evaluation

Alessandro Oldani, Luigi Ferini-Strambi, Marco Zucconi, Bojidar Stankov, Franco Fraschini, Salvatore Smirne

Research output: Contribution to journalArticlepeer-review


The present study objectively evaluated the efficacy of oral 5 mg day1 melatonin in advancing the sleep-wake rhythm in patients with delayed sleep phase syndrome (DSPS). Six patients underwent ambulatory sleep monitoring for 72 h before and 48 h after 1 month of melatonin treatment. In each patient melatonin was administered on the basis of his own estimated dim light melatonin onset (DLMO) delay. Mean advances in sleep onset time of 115 min and in final awakening hour of 106 min were found after treatment, with no significant changes in sleep architecture parameters. Our study objectively confirms previous data obtained by a sleep-wake subjective diary on the efficacy of melatonin DSPS.

Original languageEnglish
Pages (from-to)132-134
Number of pages3
Issue number1
Publication statusPublished - 1994


  • Ambulatory polygraphic monitoring
  • Delayed sleep phase syndrome
  • Melatonin

ASJC Scopus subject areas

  • Neuroscience(all)


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