Melatonin, circadian rhythms, and the clock genes in bipolar disorder

Francesco Benedetti, Sara Dallaspezia

Research output: Contribution to journalArticle

Abstract

Sleep disturbances and dysregulation of circadian rhythms are core elements of bipolar disorder that might be involved in its pathogenesis. It has been proposed that patients with bipolar disorder have an abnormally shifted or arrhythmic circadian system and that the disturbance of circadian rhythms may be caused by an alteration in the circadian clock machinery. Chronotherapeutic strategies based on controlled exposures to environmental stimuli that act on biological rhythms have shown good efficacy in the treatment of illness episodes, thus confirming ex juvantibus the clinical relevance of internal timing in this illness.

Original languageEnglish
Pages (from-to)488-493
Number of pages6
JournalCurrent Psychiatry Reports
Volume11
Issue number6
DOIs
Publication statusPublished - Dec 2009

ASJC Scopus subject areas

  • Psychiatry and Mental health

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