Melatonin is an efficient antioxidant

Carlo Pieri, Fausto Moroni, Maurizio Marra, Fiorella Marcheselli, Rina Recchioni

Research output: Contribution to journalArticle

108 Citations (Scopus)

Abstract

We have compared the peroxyl radical scavenger ability of melatonin with that of vitamin E, ascorbic acid (As.A.), reduced glutathione (GSH) and mannitol. All the antioxidants, except mannitol, prevented the lysis of human erythrocytes exposed to an azo-initiator of peroxyl radicals (2,2′-azo-bis(2-amidinopropane)dihydrochloride) at 37°C. The percentage of this inhibition of erythrocyte lysis varied with the concentration of antioxidants, but the efficiency was melatonin > vitamin E > As.A. > GSH. Based on the assumption that each molecule of vitamin E scavenges two peroxyl radicals, the scavenging capacity of melatonin was four peroxyl radicals/molecule.

Original languageEnglish
Pages (from-to)159-165
Number of pages7
JournalArchives of Gerontology and Geriatrics
Volume20
Issue number2
DOIs
Publication statusPublished - 1995

Fingerprint

Melatonin
Antioxidants
Vitamin E
efficiency
ability
Mannitol
Ascorbic Acid
Erythrocytes
Glutathione
perhydroxyl radical

Keywords

  • Antioxidants
  • Melatonin
  • Peroxyl radicals

ASJC Scopus subject areas

  • Ageing
  • Geriatrics and Gerontology
  • Gerontology
  • Health(social science)
  • Medicine(all)

Cite this

Melatonin is an efficient antioxidant. / Pieri, Carlo; Moroni, Fausto; Marra, Maurizio; Marcheselli, Fiorella; Recchioni, Rina.

In: Archives of Gerontology and Geriatrics, Vol. 20, No. 2, 1995, p. 159-165.

Research output: Contribution to journalArticle

Pieri, Carlo ; Moroni, Fausto ; Marra, Maurizio ; Marcheselli, Fiorella ; Recchioni, Rina. / Melatonin is an efficient antioxidant. In: Archives of Gerontology and Geriatrics. 1995 ; Vol. 20, No. 2. pp. 159-165.
@article{fd7c9c6f18234060b81e07a55041438f,
title = "Melatonin is an efficient antioxidant",
abstract = "We have compared the peroxyl radical scavenger ability of melatonin with that of vitamin E, ascorbic acid (As.A.), reduced glutathione (GSH) and mannitol. All the antioxidants, except mannitol, prevented the lysis of human erythrocytes exposed to an azo-initiator of peroxyl radicals (2,2′-azo-bis(2-amidinopropane)dihydrochloride) at 37°C. The percentage of this inhibition of erythrocyte lysis varied with the concentration of antioxidants, but the efficiency was melatonin > vitamin E > As.A. > GSH. Based on the assumption that each molecule of vitamin E scavenges two peroxyl radicals, the scavenging capacity of melatonin was four peroxyl radicals/molecule.",
keywords = "Antioxidants, Melatonin, Peroxyl radicals",
author = "Carlo Pieri and Fausto Moroni and Maurizio Marra and Fiorella Marcheselli and Rina Recchioni",
year = "1995",
doi = "10.1016/0167-4943(94)00593-V",
language = "English",
volume = "20",
pages = "159--165",
journal = "Archives of Gerontology and Geriatrics",
issn = "0167-4943",
publisher = "Elsevier Ireland Ltd",
number = "2",

}

TY - JOUR

T1 - Melatonin is an efficient antioxidant

AU - Pieri, Carlo

AU - Moroni, Fausto

AU - Marra, Maurizio

AU - Marcheselli, Fiorella

AU - Recchioni, Rina

PY - 1995

Y1 - 1995

N2 - We have compared the peroxyl radical scavenger ability of melatonin with that of vitamin E, ascorbic acid (As.A.), reduced glutathione (GSH) and mannitol. All the antioxidants, except mannitol, prevented the lysis of human erythrocytes exposed to an azo-initiator of peroxyl radicals (2,2′-azo-bis(2-amidinopropane)dihydrochloride) at 37°C. The percentage of this inhibition of erythrocyte lysis varied with the concentration of antioxidants, but the efficiency was melatonin > vitamin E > As.A. > GSH. Based on the assumption that each molecule of vitamin E scavenges two peroxyl radicals, the scavenging capacity of melatonin was four peroxyl radicals/molecule.

AB - We have compared the peroxyl radical scavenger ability of melatonin with that of vitamin E, ascorbic acid (As.A.), reduced glutathione (GSH) and mannitol. All the antioxidants, except mannitol, prevented the lysis of human erythrocytes exposed to an azo-initiator of peroxyl radicals (2,2′-azo-bis(2-amidinopropane)dihydrochloride) at 37°C. The percentage of this inhibition of erythrocyte lysis varied with the concentration of antioxidants, but the efficiency was melatonin > vitamin E > As.A. > GSH. Based on the assumption that each molecule of vitamin E scavenges two peroxyl radicals, the scavenging capacity of melatonin was four peroxyl radicals/molecule.

KW - Antioxidants

KW - Melatonin

KW - Peroxyl radicals

UR - http://www.scopus.com/inward/record.url?scp=0028940520&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028940520&partnerID=8YFLogxK

U2 - 10.1016/0167-4943(94)00593-V

DO - 10.1016/0167-4943(94)00593-V

M3 - Article

C2 - 15374244

AN - SCOPUS:0028940520

VL - 20

SP - 159

EP - 165

JO - Archives of Gerontology and Geriatrics

JF - Archives of Gerontology and Geriatrics

SN - 0167-4943

IS - 2

ER -