Melatonin is an efficient antioxidant

Carlo Pieri, Fausto Moroni, Maurizio Marra, Fiorella Marcheselli, Rina Recchioni

Research output: Contribution to journalArticlepeer-review


We have compared the peroxyl radical scavenger ability of melatonin with that of vitamin E, ascorbic acid (As.A.), reduced glutathione (GSH) and mannitol. All the antioxidants, except mannitol, prevented the lysis of human erythrocytes exposed to an azo-initiator of peroxyl radicals (2,2′-azo-bis(2-amidinopropane)dihydrochloride) at 37°C. The percentage of this inhibition of erythrocyte lysis varied with the concentration of antioxidants, but the efficiency was melatonin > vitamin E > As.A. > GSH. Based on the assumption that each molecule of vitamin E scavenges two peroxyl radicals, the scavenging capacity of melatonin was four peroxyl radicals/molecule.

Original languageEnglish
Pages (from-to)159-165
Number of pages7
JournalArchives of Gerontology and Geriatrics
Issue number2
Publication statusPublished - 1995


  • Antioxidants
  • Melatonin
  • Peroxyl radicals

ASJC Scopus subject areas

  • Ageing
  • Geriatrics and Gerontology
  • Gerontology
  • Health(social science)
  • Medicine(all)


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