Abstract
Recent observations have demonstrated that the pineal hormone melatonin (MLT) plays a role in the neuroendocrine control of the cardiovascular system. On the other hand, it has been observed that the cardiac hormone α-atrial natriuretic peptide (ANP) may regulate the neuroendocrine functions. The present study was carried out to investigate the possible relationship between cardiac and pineal endocrine functions. Six healthy volunteers were treated on two different occasions with placebo or ANP at a dose of 0.1 mg i.v. as a bolus. An increase of > 100% in MLT serum levels was seen in 2/6 subjects. These preliminary results would suggest that ANP may play a role in the regulation of MLT secretion. Further studies will be needed to define better the cardiac-pineal interactions.
| Original language | English |
|---|---|
| Pages (from-to) | 850-852 |
| Number of pages | 3 |
| Journal | Journal of Cardiovascular Pharmacology |
| Volume | 16 |
| Issue number | 5 |
| Publication status | Published - 1990 |
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Keywords
- Atrial natriuretic hormone
- Cardiovascular system
- Melatonin
- Neuroendocrine function
- Pineal gland
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
- Pharmacology
Cite this
Melatonin response to atrial natriuretic peptide administration in healthy volunteers. / Lissoni, P.; Pelizzoni, F.; Grugni, G.; Guzzaloni, G.; Mauri, O.; Archili, C.; Galli, M. A.; Morabito, F.
In: Journal of Cardiovascular Pharmacology, Vol. 16, No. 5, 1990, p. 850-852.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Melatonin response to atrial natriuretic peptide administration in healthy volunteers
AU - Lissoni, P.
AU - Pelizzoni, F.
AU - Grugni, G.
AU - Guzzaloni, G.
AU - Mauri, O.
AU - Archili, C.
AU - Galli, M. A.
AU - Morabito, F.
PY - 1990
Y1 - 1990
N2 - Recent observations have demonstrated that the pineal hormone melatonin (MLT) plays a role in the neuroendocrine control of the cardiovascular system. On the other hand, it has been observed that the cardiac hormone α-atrial natriuretic peptide (ANP) may regulate the neuroendocrine functions. The present study was carried out to investigate the possible relationship between cardiac and pineal endocrine functions. Six healthy volunteers were treated on two different occasions with placebo or ANP at a dose of 0.1 mg i.v. as a bolus. An increase of > 100% in MLT serum levels was seen in 2/6 subjects. These preliminary results would suggest that ANP may play a role in the regulation of MLT secretion. Further studies will be needed to define better the cardiac-pineal interactions.
AB - Recent observations have demonstrated that the pineal hormone melatonin (MLT) plays a role in the neuroendocrine control of the cardiovascular system. On the other hand, it has been observed that the cardiac hormone α-atrial natriuretic peptide (ANP) may regulate the neuroendocrine functions. The present study was carried out to investigate the possible relationship between cardiac and pineal endocrine functions. Six healthy volunteers were treated on two different occasions with placebo or ANP at a dose of 0.1 mg i.v. as a bolus. An increase of > 100% in MLT serum levels was seen in 2/6 subjects. These preliminary results would suggest that ANP may play a role in the regulation of MLT secretion. Further studies will be needed to define better the cardiac-pineal interactions.
KW - Atrial natriuretic hormone
KW - Cardiovascular system
KW - Melatonin
KW - Neuroendocrine function
KW - Pineal gland
UR - http://www.scopus.com/inward/record.url?scp=0025049194&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025049194&partnerID=8YFLogxK
M3 - Article
C2 - 1703611
AN - SCOPUS:0025049194
VL - 16
SP - 850
EP - 852
JO - Journal of Cardiovascular Pharmacology
JF - Journal of Cardiovascular Pharmacology
SN - 0160-2446
IS - 5
ER -