Melatonin response to atrial natriuretic peptide administration in healthy volunteers

P. Lissoni, F. Pelizzoni, G. Grugni, G. Guzzaloni, O. Mauri, C. Archili, M. A. Galli, F. Morabito

Research output: Contribution to journalArticlepeer-review


Recent observations have demonstrated that the pineal hormone melatonin (MLT) plays a role in the neuroendocrine control of the cardiovascular system. On the other hand, it has been observed that the cardiac hormone α-atrial natriuretic peptide (ANP) may regulate the neuroendocrine functions. The present study was carried out to investigate the possible relationship between cardiac and pineal endocrine functions. Six healthy volunteers were treated on two different occasions with placebo or ANP at a dose of 0.1 mg i.v. as a bolus. An increase of > 100% in MLT serum levels was seen in 2/6 subjects. These preliminary results would suggest that ANP may play a role in the regulation of MLT secretion. Further studies will be needed to define better the cardiac-pineal interactions.

Original languageEnglish
Pages (from-to)850-852
Number of pages3
JournalJournal of Cardiovascular Pharmacology
Issue number5
Publication statusPublished - 1990


  • Atrial natriuretic hormone
  • Cardiovascular system
  • Melatonin
  • Neuroendocrine function
  • Pineal gland

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pharmacology


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