Melatonin response to atrial natriuretic peptide administration in healthy volunteers

P. Lissoni; F. Pelizzoni; G. Grugni; G. Guzzaloni; O. Mauri; C. Archili; M. A. Galli; F. Morabito

Melatonin response to atrial natriuretic peptide administration in healthy volunteers

P. Lissoni, F. Pelizzoni, G. Grugni, G. Guzzaloni, O. Mauri, C. Archili, M. A. Galli, F. Morabito

Fondazione Istituto Auxologico Italiano

Research output: Contribution to journal › Article › peer-review

Abstract

Recent observations have demonstrated that the pineal hormone melatonin (MLT) plays a role in the neuroendocrine control of the cardiovascular system. On the other hand, it has been observed that the cardiac hormone α-atrial natriuretic peptide (ANP) may regulate the neuroendocrine functions. The present study was carried out to investigate the possible relationship between cardiac and pineal endocrine functions. Six healthy volunteers were treated on two different occasions with placebo or ANP at a dose of 0.1 mg i.v. as a bolus. An increase of > 100% in MLT serum levels was seen in 2/6 subjects. These preliminary results would suggest that ANP may play a role in the regulation of MLT secretion. Further studies will be needed to define better the cardiac-pineal interactions.

Original language	English
Pages (from-to)	850-852
Number of pages	3
Journal	Journal of Cardiovascular Pharmacology
Volume	16
Issue number	5
Publication status	Published - 1990

Keywords

Atrial natriuretic hormone
Cardiovascular system
Melatonin
Neuroendocrine function
Pineal gland

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine
Pharmacology

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title = "Melatonin response to atrial natriuretic peptide administration in healthy volunteers",

abstract = "Recent observations have demonstrated that the pineal hormone melatonin (MLT) plays a role in the neuroendocrine control of the cardiovascular system. On the other hand, it has been observed that the cardiac hormone α-atrial natriuretic peptide (ANP) may regulate the neuroendocrine functions. The present study was carried out to investigate the possible relationship between cardiac and pineal endocrine functions. Six healthy volunteers were treated on two different occasions with placebo or ANP at a dose of 0.1 mg i.v. as a bolus. An increase of > 100% in MLT serum levels was seen in 2/6 subjects. These preliminary results would suggest that ANP may play a role in the regulation of MLT secretion. Further studies will be needed to define better the cardiac-pineal interactions.",

keywords = "Atrial natriuretic hormone, Cardiovascular system, Melatonin, Neuroendocrine function, Pineal gland",

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T1 - Melatonin response to atrial natriuretic peptide administration in healthy volunteers

AU - Lissoni, P.

AU - Pelizzoni, F.

AU - Grugni, G.

AU - Guzzaloni, G.

AU - Mauri, O.

AU - Archili, C.

AU - Galli, M. A.

AU - Morabito, F.

PY - 1990

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N2 - Recent observations have demonstrated that the pineal hormone melatonin (MLT) plays a role in the neuroendocrine control of the cardiovascular system. On the other hand, it has been observed that the cardiac hormone α-atrial natriuretic peptide (ANP) may regulate the neuroendocrine functions. The present study was carried out to investigate the possible relationship between cardiac and pineal endocrine functions. Six healthy volunteers were treated on two different occasions with placebo or ANP at a dose of 0.1 mg i.v. as a bolus. An increase of > 100% in MLT serum levels was seen in 2/6 subjects. These preliminary results would suggest that ANP may play a role in the regulation of MLT secretion. Further studies will be needed to define better the cardiac-pineal interactions.

AB - Recent observations have demonstrated that the pineal hormone melatonin (MLT) plays a role in the neuroendocrine control of the cardiovascular system. On the other hand, it has been observed that the cardiac hormone α-atrial natriuretic peptide (ANP) may regulate the neuroendocrine functions. The present study was carried out to investigate the possible relationship between cardiac and pineal endocrine functions. Six healthy volunteers were treated on two different occasions with placebo or ANP at a dose of 0.1 mg i.v. as a bolus. An increase of > 100% in MLT serum levels was seen in 2/6 subjects. These preliminary results would suggest that ANP may play a role in the regulation of MLT secretion. Further studies will be needed to define better the cardiac-pineal interactions.

KW - Atrial natriuretic hormone

KW - Cardiovascular system

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KW - Neuroendocrine function

KW - Pineal gland

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