Melatonin versus placebo in the prophylaxis of cluster headache: A double-blind pilot study with parallel groups

M. Leone; D. D'Amico; F. Moschiano; F. Fraschini; G. Bussone

doi:10.1046/j.1468-2982.1996.1607494.x

Melatonin versus placebo in the prophylaxis of cluster headache: A double-blind pilot study with parallel groups

M. Leone, D. D'Amico, F. Moschiano, F. Fraschini, G. Bussone

Fondazione IRCCS Istituto Neurologico "C. Besta"

Research output: Contribution to journal › Article › peer-review

Abstract

A fall in nocturnal plasma melatonin occurs in patients with cluster headache, suggesting that melatonin may play a role in the promotion of attacks. During a cluster period, we administered melatonin to 20 cluster headache patients (2 primary chronic, 18 episodic) in a double-blind placebo-controlled study of oral melatonin 10 mg (n=10) or placebo (n=10) for 14 days taken in a single evening dose. Headache frequency was significantly reduced (ANOVA, p

Original language	English
Pages (from-to)	494-496
Number of pages	3
Journal	Cephalalgia
Volume	16
Issue number	7
DOIs	https://doi.org/10.1046/j.1468-2982.1996.1607494.x
Publication status	Published - 1996

Keywords

Cluster headache
Melatonin
Pathogenesis
Prophylaxis

ASJC Scopus subject areas

Clinical Neurology

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AU - Bussone, G.

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