Melatonin versus placebo in the prophylaxis of cluster headache: A double-blind pilot study with parallel groups

M. Leone, D. D'Amico, F. Moschiano, F. Fraschini, G. Bussone

Research output: Contribution to journalArticlepeer-review

Abstract

A fall in nocturnal plasma melatonin occurs in patients with cluster headache, suggesting that melatonin may play a role in the promotion of attacks. During a cluster period, we administered melatonin to 20 cluster headache patients (2 primary chronic, 18 episodic) in a double-blind placebo-controlled study of oral melatonin 10 mg (n=10) or placebo (n=10) for 14 days taken in a single evening dose. Headache frequency was significantly reduced (ANOVA, p

Original languageEnglish
Pages (from-to)494-496
Number of pages3
JournalCephalalgia
Volume16
Issue number7
DOIs
Publication statusPublished - 1996

Keywords

  • Cluster headache
  • Melatonin
  • Pathogenesis
  • Prophylaxis

ASJC Scopus subject areas

  • Clinical Neurology

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