Members of the NF-κB family expressed in zones of active neurogenesis in the postnatal and adult mouse brain

Suzanne Denis-Donini, Andrea Caprini, Carolina Frassoni, Mariagrazia Grilli

Research output: Contribution to journalArticle

Abstract

The Rel/NF-κB family of transcription factors is implicated in cell proliferation, cell death, cell migration and cell interactions. Here, we examined by immunohistochemistry the expression pattern of various members of this family during postnatal telencephalon development and during adulthood, and we used neuronal and glial markers to identify the cells types where they are expressed. Distinct Rel/NF-κB proteins are highly expressed postnatally in the subventricular zone and in the rostral migratory stream. In particular, Rel A and p50 are expressed in radial glial cells, in migrating neuron precursors and in a population belonging to the astrocytic lineage. Rel B, on the other hand, is only expressed in migrating neuron precursors, whereas c-Rel is present in a few cells located at the edges of the rostral migratory stream. The expression of Rel A and p50 persists into adulthood, particularly in subventricular zone astrocyte-like cells and in migrating neuron precursors, respectively. The selective expression of NF-κB members in the postnatal subventricular zone and rostral migratory stream and their persistence into adulthood in regions of ongoing neurogenesis suggests possible mechanisms linking NF-κB expression with cell proliferation and migration. Their presence in actively proliferating progenitor cells, detected by BrdU staining, further suggests that NF-κB may be part of a signaling pathway that is important for neurogenesis.

Original languageEnglish
Pages (from-to)81-89
Number of pages9
JournalDevelopmental Brain Research
Volume154
Issue number1
DOIs
Publication statusPublished - Jan 1 2005

Keywords

  • Postnatal neurogenesis
  • Radial glia
  • Stem cell
  • Subventricular zone
  • Transcription factor

ASJC Scopus subject areas

  • Developmental Biology
  • Developmental Neuroscience

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