Membrane abnormalities of pyruvate kinase deficient red cells

A. Zanella, A. Brovelli, A. Mantovani, C. Izzo, P. Rebulla, C. Balduini

Research output: Contribution to journalArticlepeer-review

Abstract

Two experimental systems have been applied to the study of PK-deficient red cells in an attempt to reveal possible membrane abnormalities of these erythrocytes: the glycoprotein self-digestion of intact erythrocytes during in vitro incubation at 37°C; and the red cell sensitivity to the lytic action of mouse macrophages. PK-deficient erythrocytes display a more precocious than normal membrane glycoprotein self-digestion and are much more susceptible than normal to the cytotoxic activity of mouse macrophages. This latter effect is more pronounced in young than in old PK-deficient red cells. These observations indicate the existence of membrane abnormality in PK-deficient red cells other than those so far suspected.

Original languageEnglish
Pages (from-to)101-108
Number of pages8
JournalBritish Journal of Haematology
Volume42
Issue number1
Publication statusPublished - 1979

ASJC Scopus subject areas

  • Hematology

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