Two experimental systems have been applied to the study of PK-deficient red cells in an attempt to reveal possible membrane abnormalities of these erythrocytes: the glycoprotein self-digestion of intact erythrocytes during in vitro incubation at 37°C; and the red cell sensitivity to the lytic action of mouse macrophages. PK-deficient erythrocytes display a more precocious than normal membrane glycoprotein self-digestion and are much more susceptible than normal to the cytotoxic activity of mouse macrophages. This latter effect is more pronounced in young than in old PK-deficient red cells. These observations indicate the existence of membrane abnormality in PK-deficient red cells other than those so far suspected.
|Number of pages||8|
|Journal||British Journal of Haematology|
|Publication status||Published - 1979|
ASJC Scopus subject areas