Membrane fluidity affects tumor-cell motility, invasion and lung-colonizing potential

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Abstract

Membrane fluidity, determined by steady-state fluorescence polarization measurements, was correlated with metastatic capacity of murine tumor-cell lines. A correlation was observed in cell lines with different metastatic potential, and was confirmed when their lung-colonizing ability was modulated by alteration of either the membrane lipid composition or the culture conditions. Two cellular functions, motility and basement membrane invasion, were affected by the membrane lipid composition, and might explain the role of membrane fluidity observed in cancer metastasis.

Original languageEnglish
Pages (from-to)707-713
Number of pages7
JournalInternational Journal of Cancer
Volume44
Issue number4
Publication statusPublished - 1989

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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