TY - JOUR
T1 - Membrane fluidity affects tumor-cell motility, invasion and lung-colonizing potential
AU - Taraboletti, G.
AU - Perin, L.
AU - Bottazzi, B.
AU - Mantovani, A.
AU - Giavazzi, R.
AU - Salmona, M.
PY - 1989
Y1 - 1989
N2 - Membrane fluidity, determined by steady-state fluorescence polarization measurements, was correlated with metastatic capacity of murine tumor-cell lines. A correlation was observed in cell lines with different metastatic potential, and was confirmed when their lung-colonizing ability was modulated by alteration of either the membrane lipid composition or the culture conditions. Two cellular functions, motility and basement membrane invasion, were affected by the membrane lipid composition, and might explain the role of membrane fluidity observed in cancer metastasis.
AB - Membrane fluidity, determined by steady-state fluorescence polarization measurements, was correlated with metastatic capacity of murine tumor-cell lines. A correlation was observed in cell lines with different metastatic potential, and was confirmed when their lung-colonizing ability was modulated by alteration of either the membrane lipid composition or the culture conditions. Two cellular functions, motility and basement membrane invasion, were affected by the membrane lipid composition, and might explain the role of membrane fluidity observed in cancer metastasis.
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M3 - Article
C2 - 2793242
AN - SCOPUS:0024443749
VL - 44
SP - 707
EP - 713
JO - International Journal of Cancer
JF - International Journal of Cancer
SN - 0020-7136
IS - 4
ER -