The expression of membrane immunoglobulin (mIg) was examined in three cloned MPC11 derived mouse myeloma cell lines. Membrane immunofluorescence studies demonstrated that IgG(2b) producer cells (P1) had complete IgG molecules, L chain producer (L1) had only L chain determinants and nonproducer (NP2) did not have any Ig determinants on the cell surface. An Ig receptor, with characteristics different from B lymphocyte Fc receptor, was found to be present on secreting cells (P1 or L1), but not on the NP2 cell variant. The data reported in the present paper indicate that the expression of mIg and of the Ig receptor molecule is clearly correlated with the process of secretion. In the light of previous data reported on Ig secretion, a model is proposed which correlates the process of secretion with the expression not only of mIg, but also of the receptor for Ig.
|Number of pages||6|
|Journal||European Journal of Immunology|
|Publication status||Published - 1976|
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