Membrane phenotype and functional behaviour of T lymphocytes in multiple myeloma: Correlation with clinical stages of the disease

F. Lauria, R. Foa, M. Cavo, M. Gobbi, D. Raspadori, M. C. Giubellino, P. L. Tazzari, S. Tura

Research output: Contribution to journalArticlepeer-review

Abstract

The distribution of T lymphocyte subsets was assessed using monoclonal antibodies (MoAbs) in 44 untreated patients with multiple myeloma (MM) subdivided according to the clinical stage of the disease. A significant reduction (P <0.001) of T lymphocytes was observed only in stage II and III patients. The proportion and absolute number of OKT4 positive cells (helper/inducer phenotype) were significantly reduced in all stages of the disease; this quantitative abnormality was more pronounced in advanced disease. While the proportion of OKT8 positive cells (suppressor/cytotoxic phenotype) was increased above normal in all stages, the absolute number (of OKT8 positive cells) was high only in stage I patients; on the contrary in stage II-III patients the total OKT8 count was reduced compared with normal controls. A significantly reduced OKT4/OKT8 ratio was found in both groups of patients (P <0.005). Functional studies, carried out on the unfractionated T cells of patients with MM, demonstrated a consistent helper defect in the ability to induce the differentiation of normal B lymphocytes into antibody producing cells in a pokeweed mitogen driven system. However, the removal of OKT8 positive cells produces a significant increase in helper capacity, suggesting that the reduced helper function of T lymphocytes in toto is probably due to excessive suppressor activity. The possible immunoregulatory role of MM T cell disease is discussed.

Original languageEnglish
Pages (from-to)653-658
Number of pages6
JournalClinical and Experimental Immunology
Volume56
Issue number3
Publication statusPublished - 1984

ASJC Scopus subject areas

  • Immunology

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