Out of 127 patients affected by SLE-Glomerulonephritis (GN), 20 (15%) showed diffuse thickening of GBM with continuous subepithelial deposits, featuring 'membranous' GN. According to the histological, immunohistochemical and ultrastructure features, the patients were divided into 2 groups: 1) pure membranous GN with no cellular proliferation, 12 patients: and 2) membranous GN with diffuse segmental mesangial proliferation; 8 patients. Group 2 showed a larger incidence of subendothelial deposits (75% vs 16%), intraluminal thrombi (37% vs 16%), interstitial infiltrates (50% vs 16%) and a higher index of mean histological 'activity' (2.8 vs 05). No difference was noted between the two groups as regards sex, age at onset of SLE, extrarenal involvement and serological data. Group 2 presented a smaller interval between the clinical onset of SLE and GN (3 vs 50 months), a higher incidence of nephrotic syndrome (75% vs 45%) and of chronic renal failure (13% vs 0) after a 59 ± 40 months followup. In SLE, the presence of mesangial proliferation in membranous GN is associated with renal symptoms more frequently observed in 'pure' proliferative GN than in 'pure' membranous GN.
|Number of pages||5|
|Publication status||Published - 1980|
ASJC Scopus subject areas