LA GLOMERULONEFRITE MEMBRANOSA (GNM) IN CORSO DI LUPUS ERITEMATODES SISTEMICO (LES). STUDIO CLINICO E ISTOLOGICO IN 20 CASI

Translated title of the contribution: Membranous glomerulonephritis in systemic lupus erythematosus. A clinico-histological study on 20 patients

F. Ferrario, S. Bertoli, G. Banfi, M. Messina, G. Mazzucco, L. Guerra, G. Barbiano Di Belgioioso, A. Bucci

Research output: Contribution to journalArticle

Abstract

Out of 127 patients affected by SLE-Glomerulonephritis (GN), 20 (15%) showed diffuse thickening of GBM with continuous subepithelial deposits, featuring 'membranous' GN. According to the histological, immunohistochemical and ultrastructure features, the patients were divided into 2 groups: 1) pure membranous GN with no cellular proliferation, 12 patients: and 2) membranous GN with diffuse segmental mesangial proliferation; 8 patients. Group 2 showed a larger incidence of subendothelial deposits (75% vs 16%), intraluminal thrombi (37% vs 16%), interstitial infiltrates (50% vs 16%) and a higher index of mean histological 'activity' (2.8 vs 05). No difference was noted between the two groups as regards sex, age at onset of SLE, extrarenal involvement and serological data. Group 2 presented a smaller interval between the clinical onset of SLE and GN (3 vs 50 months), a higher incidence of nephrotic syndrome (75% vs 45%) and of chronic renal failure (13% vs 0) after a 59 ± 40 months followup. In SLE, the presence of mesangial proliferation in membranous GN is associated with renal symptoms more frequently observed in 'pure' proliferative GN than in 'pure' membranous GN.

Original languageItalian
Pages (from-to)549-553
Number of pages5
JournalMinerva Nefrologica
Volume27
Issue number4
Publication statusPublished - 1980

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ASJC Scopus subject areas

  • Medicine(all)

Cite this

Ferrario, F., Bertoli, S., Banfi, G., Messina, M., Mazzucco, G., Guerra, L., Barbiano Di Belgioioso, G., & Bucci, A. (1980). LA GLOMERULONEFRITE MEMBRANOSA (GNM) IN CORSO DI LUPUS ERITEMATODES SISTEMICO (LES). STUDIO CLINICO E ISTOLOGICO IN 20 CASI. Minerva Nefrologica, 27(4), 549-553.