Memory guided saccades in mesial temporal lobe epilepsy with hippocampal sclerosis

S. Colnaghi, C. Arbasino, G. Beltrami, C. A. Galimberti, V. Cosi, M. Versino

Research output: Contribution to journalArticlepeer-review


Objective: Mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS) may involve extrahippocampal areas of structural and functional damage. The incidence and the features of this damage are still a matter of debate and vary depending on the method applied. Memory guided saccades (MGSs) with a memorization delay longer than 20 s can be used reliably to evaluate the parahippocampal cortex. Methods: MGSs with 3 and 30 s memorization delays were recorded with the search coil technique in six patients affected by right MTLE-HS, and in 13 healthy controls. Results: The patients were not able to reduce the MGSs residual amplitude error after the first saccade with a 30 s memorization delay. This finding was more evident with leftward saccades. Conclusions: MGS abnormalities suggested the functional involvement of the right parahippocampal cortex in most of the patients with MTLE-HS, and this supports the clinical and anatomopathological heterogeneity of the disease. Significance: MGSs can be used in patients with right MTLE-HS to detect a possible functional involvement of the ipsilateral parahippocampal cortex.

Original languageEnglish
Pages (from-to)2392-2398
Number of pages7
JournalClinical Neurophysiology
Issue number11
Publication statusPublished - Nov 2006


  • Memory guided saccades
  • Mesial temporal lobe epilepsy
  • Parahippocampal cortex
  • Spatial memory

ASJC Scopus subject areas

  • Clinical Neurology
  • Physiology (medical)
  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Sensory Systems


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