Memory outcome 2 years after anterior temporal lobectomy in patients with drug-resistant epilepsy

Liliana G. Grammaldo, Giancarlo Di Gennaro, Teresa Giampà, Marco De Risi, Giulio N. Meldolesi, Addolorata Mascia, Antonio Sparano, Vincenzo Esposito, Pier Paolo Quarato, Angelo Picardi

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Purpose: Memory decline is often observed after anterior temporal lobectomy (ATL), particularly in patients with dominant hemisphere resections. However, the follow-up length has been 1 year or less in most studies. Our aims were to examine postoperative memory changes over a longer period and to identify baseline demographic and clinical predictors of memory outcome. Methods: We administered material-specific memory tests at baseline, and 1 and 2 years after surgery to 82 consecutive right-handed patients (52% males) who underwent ATL for drug-resistant temporal lobe epilepsy (TLE) (35 left, 47 right) after a non-invasive presurgical protocol. Repeated measures multivariate analysis of variance (RM-MANOVA) was used to examine the relationship between changes in memory tests scores over time and side of TLE and pathology. Also, standardized residual change scores were calculated for each memory test and entered in multiple linear regression models aimed at identifying baseline predictors of better memory outcome. Results: RM-MANOVA revealed a significant change in memory test scores over time, with an interaction between time and side of surgery, as 2 years after surgery patients with RTLE were improved while patients with LTLE were not worse as compared with baseline. Pathology was not associated with changes in memory scores. In multiple regression analysis, significant associations were found between right TLE and greater improvement in verbal memory, younger age and greater improvement in visuospatial memory, and male gender and greater improvement in both verbal and visuospatial memory. Conclusions: Our results suggest that the long-term memory outcome of TLE patients undergoing ATL without invasive presurgical assessment may be good in most cases not only for right-sided but also for left-sided resections.

Original languageEnglish
Pages (from-to)139-144
Number of pages6
JournalSeizure
Volume18
Issue number2
DOIs
Publication statusPublished - Mar 2009

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Anterior Temporal Lobectomy
Temporal Lobe Epilepsy
Drug Resistant Epilepsy
Linear Models
Analysis of Variance
Multivariate Analysis
Pathology
Long-Term Memory
Patient Rights

Keywords

  • Epilepsy surgery
  • Memory outcome
  • Neuropsychological evaluation
  • Temporal lobe epilepsy

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Memory outcome 2 years after anterior temporal lobectomy in patients with drug-resistant epilepsy. / Grammaldo, Liliana G.; Di Gennaro, Giancarlo; Giampà, Teresa; De Risi, Marco; Meldolesi, Giulio N.; Mascia, Addolorata; Sparano, Antonio; Esposito, Vincenzo; Quarato, Pier Paolo; Picardi, Angelo.

In: Seizure, Vol. 18, No. 2, 03.2009, p. 139-144.

Research output: Contribution to journalArticle

Grammaldo, Liliana G. ; Di Gennaro, Giancarlo ; Giampà, Teresa ; De Risi, Marco ; Meldolesi, Giulio N. ; Mascia, Addolorata ; Sparano, Antonio ; Esposito, Vincenzo ; Quarato, Pier Paolo ; Picardi, Angelo. / Memory outcome 2 years after anterior temporal lobectomy in patients with drug-resistant epilepsy. In: Seizure. 2009 ; Vol. 18, No. 2. pp. 139-144.
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T1 - Memory outcome 2 years after anterior temporal lobectomy in patients with drug-resistant epilepsy

AU - Grammaldo, Liliana G.

AU - Di Gennaro, Giancarlo

AU - Giampà, Teresa

AU - De Risi, Marco

AU - Meldolesi, Giulio N.

AU - Mascia, Addolorata

AU - Sparano, Antonio

AU - Esposito, Vincenzo

AU - Quarato, Pier Paolo

AU - Picardi, Angelo

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N2 - Purpose: Memory decline is often observed after anterior temporal lobectomy (ATL), particularly in patients with dominant hemisphere resections. However, the follow-up length has been 1 year or less in most studies. Our aims were to examine postoperative memory changes over a longer period and to identify baseline demographic and clinical predictors of memory outcome. Methods: We administered material-specific memory tests at baseline, and 1 and 2 years after surgery to 82 consecutive right-handed patients (52% males) who underwent ATL for drug-resistant temporal lobe epilepsy (TLE) (35 left, 47 right) after a non-invasive presurgical protocol. Repeated measures multivariate analysis of variance (RM-MANOVA) was used to examine the relationship between changes in memory tests scores over time and side of TLE and pathology. Also, standardized residual change scores were calculated for each memory test and entered in multiple linear regression models aimed at identifying baseline predictors of better memory outcome. Results: RM-MANOVA revealed a significant change in memory test scores over time, with an interaction between time and side of surgery, as 2 years after surgery patients with RTLE were improved while patients with LTLE were not worse as compared with baseline. Pathology was not associated with changes in memory scores. In multiple regression analysis, significant associations were found between right TLE and greater improvement in verbal memory, younger age and greater improvement in visuospatial memory, and male gender and greater improvement in both verbal and visuospatial memory. Conclusions: Our results suggest that the long-term memory outcome of TLE patients undergoing ATL without invasive presurgical assessment may be good in most cases not only for right-sided but also for left-sided resections.

AB - Purpose: Memory decline is often observed after anterior temporal lobectomy (ATL), particularly in patients with dominant hemisphere resections. However, the follow-up length has been 1 year or less in most studies. Our aims were to examine postoperative memory changes over a longer period and to identify baseline demographic and clinical predictors of memory outcome. Methods: We administered material-specific memory tests at baseline, and 1 and 2 years after surgery to 82 consecutive right-handed patients (52% males) who underwent ATL for drug-resistant temporal lobe epilepsy (TLE) (35 left, 47 right) after a non-invasive presurgical protocol. Repeated measures multivariate analysis of variance (RM-MANOVA) was used to examine the relationship between changes in memory tests scores over time and side of TLE and pathology. Also, standardized residual change scores were calculated for each memory test and entered in multiple linear regression models aimed at identifying baseline predictors of better memory outcome. Results: RM-MANOVA revealed a significant change in memory test scores over time, with an interaction between time and side of surgery, as 2 years after surgery patients with RTLE were improved while patients with LTLE were not worse as compared with baseline. Pathology was not associated with changes in memory scores. In multiple regression analysis, significant associations were found between right TLE and greater improvement in verbal memory, younger age and greater improvement in visuospatial memory, and male gender and greater improvement in both verbal and visuospatial memory. Conclusions: Our results suggest that the long-term memory outcome of TLE patients undergoing ATL without invasive presurgical assessment may be good in most cases not only for right-sided but also for left-sided resections.

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