MENINGITI CARCINOMATOSE: ASPETTI CLINICI E DECORSO IN 5 PAZIENTI TRATTATI CON METOTREXATE ENDORACHIDE

A. Pietrangeli; L. Bove; P. Innocenti; A. Pace; B. Jandolo

MENINGITI CARCINOMATOSE: ASPETTI CLINICI E DECORSO IN 5 PAZIENTI TRATTATI CON METOTREXATE ENDORACHIDE

Translated title of the contribution: Meningeal carcinomatosis: Clinical findings and course in 5 patients treated with intrathecal methotrexate

A. Pietrangeli, L. Bove, P. Innocenti, A. Pace, B. Jandolo

Istituto Regina Elena

Research output: Contribution to journal › Article › peer-review

Abstract

From a group of 20 patients studied in our center from 1988 to 1993 we drew out 5 patients that collect most of signs and symptoms of meningeal carcinomatosis. Each patient, excepting case 5, was given Methotrexate (MTX), 10 mg/m2 weekly intrathecally by lumbar puncture until the results of CSF cytodiagnosis were negative. Patients 5 was treated, without benefit, only with whole brain radiotherapy. One patient had a lung cancer, the others had breast adc. In this group of patients the utility of MTX administered intrathecally by lumbar puncture is confirmed. The treatment improves or stabilizes neurological symptomatology and at times prolongs survival of patients.

Translated title of the contribution	Meningeal carcinomatosis: Clinical findings and course in 5 patients treated with intrathecal methotrexate
Original language	Italian
Pages (from-to)	671-675
Number of pages	5
Journal	Rivista di Neurobiologia
Volume	41
Issue number	5
Publication status	Published - 1995

ASJC Scopus subject areas

Neuroscience(all)

Cite this

@article{ba73f7864772449c914dfa58dd493a74,

title = "MENINGITI CARCINOMATOSE: ASPETTI CLINICI E DECORSO IN 5 PAZIENTI TRATTATI CON METOTREXATE ENDORACHIDE",

abstract = "From a group of 20 patients studied in our center from 1988 to 1993 we drew out 5 patients that collect most of signs and symptoms of meningeal carcinomatosis. Each patient, excepting case 5, was given Methotrexate (MTX), 10 mg/m2 weekly intrathecally by lumbar puncture until the results of CSF cytodiagnosis were negative. Patients 5 was treated, without benefit, only with whole brain radiotherapy. One patient had a lung cancer, the others had breast adc. In this group of patients the utility of MTX administered intrathecally by lumbar puncture is confirmed. The treatment improves or stabilizes neurological symptomatology and at times prolongs survival of patients.",

keywords = "intrathecal chemotherapy, meningeal carcinomatosis",

author = "A. Pietrangeli and L. Bove and P. Innocenti and A. Pace and B. Jandolo",

year = "1995",

language = "Italian",

volume = "41",

pages = "671--675",

journal = "Rivista Italiana di Neurobiologia",

issn = "0035-6336",

publisher = "Editrice Pisani s.a.s.",

number = "5",

}

TY - JOUR

T1 - MENINGITI CARCINOMATOSE

T2 - ASPETTI CLINICI E DECORSO IN 5 PAZIENTI TRATTATI CON METOTREXATE ENDORACHIDE

AU - Pietrangeli, A.

AU - Bove, L.

AU - Innocenti, P.

AU - Pace, A.

AU - Jandolo, B.

PY - 1995

Y1 - 1995

N2 - From a group of 20 patients studied in our center from 1988 to 1993 we drew out 5 patients that collect most of signs and symptoms of meningeal carcinomatosis. Each patient, excepting case 5, was given Methotrexate (MTX), 10 mg/m2 weekly intrathecally by lumbar puncture until the results of CSF cytodiagnosis were negative. Patients 5 was treated, without benefit, only with whole brain radiotherapy. One patient had a lung cancer, the others had breast adc. In this group of patients the utility of MTX administered intrathecally by lumbar puncture is confirmed. The treatment improves or stabilizes neurological symptomatology and at times prolongs survival of patients.

AB - From a group of 20 patients studied in our center from 1988 to 1993 we drew out 5 patients that collect most of signs and symptoms of meningeal carcinomatosis. Each patient, excepting case 5, was given Methotrexate (MTX), 10 mg/m2 weekly intrathecally by lumbar puncture until the results of CSF cytodiagnosis were negative. Patients 5 was treated, without benefit, only with whole brain radiotherapy. One patient had a lung cancer, the others had breast adc. In this group of patients the utility of MTX administered intrathecally by lumbar puncture is confirmed. The treatment improves or stabilizes neurological symptomatology and at times prolongs survival of patients.

KW - intrathecal chemotherapy

KW - meningeal carcinomatosis

UR - http://www.scopus.com/inward/record.url?scp=0029555938&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029555938&partnerID=8YFLogxK

M3 - Articolo

AN - SCOPUS:0029555938

VL - 41

SP - 671

EP - 675

JO - Rivista Italiana di Neurobiologia

JF - Rivista Italiana di Neurobiologia

SN - 0035-6336

IS - 5

ER -

MENINGITI CARCINOMATOSE: ASPETTI CLINICI E DECORSO IN 5 PAZIENTI TRATTATI CON METOTREXATE ENDORACHIDE

Abstract

ASJC Scopus subject areas

Other files and links

Fingerprint

Cite this