Meningeal Leukemia Diagnosed by Cytocentrifuge Study of Cerebrospinal Fluid

A Study of 631 Cerebrospinal Fluid Samples From 87 Patients

Giovanni Ricevuti, Faustino Savoldi, Giovanni Piccolo, Enrico Marchioni, Salvatore Carlo Rizzo

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Owing to improved therapy and lengthened life span, the incidence of neuromeningeal involvement in leukemia is increasing. Careful examination of the cerebrospinal fluid (CSF) is important for an early diagnosis. Among the available techniques, the use of cytocentrifugation enables us to demonstrate central nervous system leukemia even if the white blood cell count in the CSF is under 10/cu mm. We describe the results obtained by examining 631 CSF samples from 87 patients affected by acute leukemia; central nervous system luekemia was found in 22.7% of the patients suffering from acute lymphocytic leukemia and in 6.4% of those with acute nonlymphocytic leukemia (ANLL), but this ratio is higher in ANLL compared with the survival as measured in months (a ratio of 2.0 in ANLL compared with 0.50 in acute lymphocytic leukemia). A “leukemic” CSF was found in 51.5% of prophylactically treated patients and in 73.1% of the untreated ones.

Original languageEnglish
Pages (from-to)466-470
Number of pages5
JournalArchives of Neurology
Volume43
Issue number5
DOIs
Publication statusPublished - 1986

Fingerprint

Cerebrospinal Fluid
Leukemia
Acute Myeloid Leukemia
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Central Nervous System
Leukocyte Count
Early Diagnosis
Survival
Incidence
Therapeutics
Therapy
Life Span
Cells
Blood

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Meningeal Leukemia Diagnosed by Cytocentrifuge Study of Cerebrospinal Fluid : A Study of 631 Cerebrospinal Fluid Samples From 87 Patients. / Ricevuti, Giovanni; Savoldi, Faustino; Piccolo, Giovanni; Marchioni, Enrico; Rizzo, Salvatore Carlo.

In: Archives of Neurology, Vol. 43, No. 5, 1986, p. 466-470.

Research output: Contribution to journalArticle

Ricevuti, Giovanni ; Savoldi, Faustino ; Piccolo, Giovanni ; Marchioni, Enrico ; Rizzo, Salvatore Carlo. / Meningeal Leukemia Diagnosed by Cytocentrifuge Study of Cerebrospinal Fluid : A Study of 631 Cerebrospinal Fluid Samples From 87 Patients. In: Archives of Neurology. 1986 ; Vol. 43, No. 5. pp. 466-470.
@article{1b17be9f93ca4b71a37f2681fa46d912,
title = "Meningeal Leukemia Diagnosed by Cytocentrifuge Study of Cerebrospinal Fluid: A Study of 631 Cerebrospinal Fluid Samples From 87 Patients",
abstract = "Owing to improved therapy and lengthened life span, the incidence of neuromeningeal involvement in leukemia is increasing. Careful examination of the cerebrospinal fluid (CSF) is important for an early diagnosis. Among the available techniques, the use of cytocentrifugation enables us to demonstrate central nervous system leukemia even if the white blood cell count in the CSF is under 10/cu mm. We describe the results obtained by examining 631 CSF samples from 87 patients affected by acute leukemia; central nervous system luekemia was found in 22.7{\%} of the patients suffering from acute lymphocytic leukemia and in 6.4{\%} of those with acute nonlymphocytic leukemia (ANLL), but this ratio is higher in ANLL compared with the survival as measured in months (a ratio of 2.0 in ANLL compared with 0.50 in acute lymphocytic leukemia). A “leukemic” CSF was found in 51.5{\%} of prophylactically treated patients and in 73.1{\%} of the untreated ones.",
author = "Giovanni Ricevuti and Faustino Savoldi and Giovanni Piccolo and Enrico Marchioni and Rizzo, {Salvatore Carlo}",
year = "1986",
doi = "10.1001/archneur.1986.00520050046020",
language = "English",
volume = "43",
pages = "466--470",
journal = "Archives of Neurology",
issn = "0003-9942",
publisher = "American Medical Association",
number = "5",

}

TY - JOUR

T1 - Meningeal Leukemia Diagnosed by Cytocentrifuge Study of Cerebrospinal Fluid

T2 - A Study of 631 Cerebrospinal Fluid Samples From 87 Patients

AU - Ricevuti, Giovanni

AU - Savoldi, Faustino

AU - Piccolo, Giovanni

AU - Marchioni, Enrico

AU - Rizzo, Salvatore Carlo

PY - 1986

Y1 - 1986

N2 - Owing to improved therapy and lengthened life span, the incidence of neuromeningeal involvement in leukemia is increasing. Careful examination of the cerebrospinal fluid (CSF) is important for an early diagnosis. Among the available techniques, the use of cytocentrifugation enables us to demonstrate central nervous system leukemia even if the white blood cell count in the CSF is under 10/cu mm. We describe the results obtained by examining 631 CSF samples from 87 patients affected by acute leukemia; central nervous system luekemia was found in 22.7% of the patients suffering from acute lymphocytic leukemia and in 6.4% of those with acute nonlymphocytic leukemia (ANLL), but this ratio is higher in ANLL compared with the survival as measured in months (a ratio of 2.0 in ANLL compared with 0.50 in acute lymphocytic leukemia). A “leukemic” CSF was found in 51.5% of prophylactically treated patients and in 73.1% of the untreated ones.

AB - Owing to improved therapy and lengthened life span, the incidence of neuromeningeal involvement in leukemia is increasing. Careful examination of the cerebrospinal fluid (CSF) is important for an early diagnosis. Among the available techniques, the use of cytocentrifugation enables us to demonstrate central nervous system leukemia even if the white blood cell count in the CSF is under 10/cu mm. We describe the results obtained by examining 631 CSF samples from 87 patients affected by acute leukemia; central nervous system luekemia was found in 22.7% of the patients suffering from acute lymphocytic leukemia and in 6.4% of those with acute nonlymphocytic leukemia (ANLL), but this ratio is higher in ANLL compared with the survival as measured in months (a ratio of 2.0 in ANLL compared with 0.50 in acute lymphocytic leukemia). A “leukemic” CSF was found in 51.5% of prophylactically treated patients and in 73.1% of the untreated ones.

UR - http://www.scopus.com/inward/record.url?scp=0022623798&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022623798&partnerID=8YFLogxK

U2 - 10.1001/archneur.1986.00520050046020

DO - 10.1001/archneur.1986.00520050046020

M3 - Article

VL - 43

SP - 466

EP - 470

JO - Archives of Neurology

JF - Archives of Neurology

SN - 0003-9942

IS - 5

ER -