Meningeal leukemia following lymphoid blast crisis in chronic myeloid leukemia: Therapeutic implications

M. Cazzola, G. Nalli, E. Brusamolino, M. Daccò, A. Ghizzi, E. Molinari, A. Tagliabue

Research output: Contribution to journalArticle

Abstract

Five of 40 patients with chronic myeloid leukemia (CML) had lymphoid blast crisis and 4 of them achieved complete remission of metamorphosis with vincristine and prednisone. While in hematologic remission, two of these subjects developed meningeal leukemia. Clinical and biologic data indicated that the course of the disease after lymphoid blast crisis was very similar to that of acute lymphoblastic leukemia (ALL). It is suggested that patients with CML who develop lymphoid blast crisis should be treated with an intensive therapeutic protocol including early prevention of meningeal leukemia.

Original languageEnglish
Pages (from-to)257-263
Number of pages7
JournalTumori
Volume68
Issue number3
Publication statusPublished - 1982

ASJC Scopus subject areas

  • Cancer Research

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    Cazzola, M., Nalli, G., Brusamolino, E., Daccò, M., Ghizzi, A., Molinari, E., & Tagliabue, A. (1982). Meningeal leukemia following lymphoid blast crisis in chronic myeloid leukemia: Therapeutic implications. Tumori, 68(3), 257-263.