Meningeal melanomatosis

A challenge for timely diagnosis

Giulia Berzero, Luca Diamanti, Anna Luisa Di Stefano, Paola Bini, Diego Franciotta, Ilaria Imarisio, Paolo Pedrazzoli, Lorenzo Magrassi, Patrizia Morbini, Lisa Maria Farina, Stefano Bastianello, Mauro Ceroni, Enrico Marchioni

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Neoplastic meningitis is a central nervous system complication that occurs in 3-5% of patients with cancer. Although most commonly seen in patients with disseminated disease, in a small percentage of patients, it may be the initial manifestation of cancer or even primitive in origin. In the absence of cancer history, the diagnosis of neoplastic meningitis may be challenging even for expert neurologists. Prognosis is poor, with a median overall survival of weeks from diagnosis. In the retrospective study herein, we described three cases of meningeal melanomatosis in patients without previous cancer history. The patients were diagnosed with significant delay (17 to 47 weeks from symptom onset) mainly due to the deferral in performing the appropriate testing. Even when the diagnosis was suspected, investigations by MRI, cerebrospinal fluid, or both proved at times unhelpful for confirmation. Prognosis was dismal, with a median survival of 4 weeks after diagnosis. Our observations are a cue to analyze the main pitfalls in the diagnosis of neoplastic meningitis in patients without cancer history and emphasize key elements that may facilitate early diagnosis.

Original languageEnglish
Article number948497
JournalBioMed Research International
Volume2015
DOIs
Publication statusPublished - Jan 14 2015

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Meningitis
Neoplasms
Cerebrospinal fluid
Survival
Neurology
Magnetic resonance imaging
Cues
Cerebrospinal Fluid
Early Diagnosis
Central Nervous System
Retrospective Studies
Testing

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

Cite this

Meningeal melanomatosis : A challenge for timely diagnosis. / Berzero, Giulia; Diamanti, Luca; Di Stefano, Anna Luisa; Bini, Paola; Franciotta, Diego; Imarisio, Ilaria; Pedrazzoli, Paolo; Magrassi, Lorenzo; Morbini, Patrizia; Farina, Lisa Maria; Bastianello, Stefano; Ceroni, Mauro; Marchioni, Enrico.

In: BioMed Research International, Vol. 2015, 948497, 14.01.2015.

Research output: Contribution to journalArticle

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AU - Di Stefano, Anna Luisa

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AU - Franciotta, Diego

AU - Imarisio, Ilaria

AU - Pedrazzoli, Paolo

AU - Magrassi, Lorenzo

AU - Morbini, Patrizia

AU - Farina, Lisa Maria

AU - Bastianello, Stefano

AU - Ceroni, Mauro

AU - Marchioni, Enrico

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