Meningioma presenting with Cushing's syndrome: An unusual clinical presentation

Francesca Pecori Giraldi, Maria Rosa Terreni, Claudia Andreotti, Marco Losa, Roberto Lanzi, Antonio E. Pontiroli, Francesco Cavagnini

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

We report a patient with a meningioma presenting with Cushing's syndrome, an unprecedented paraneoplastic presentation. Molecular studies, bioassay, and high-performance liquid chromatography of tumor specimens demonstrated the synthesis and secretion of bioactive corticotropin-releasing hormone. To our knowledge, this appears to be the first report of a hormone-secreting meningioma and, further, the first clearly proven case of Cushing's syndrome due to ectopic corticotropin-releasing hormone secretion without concomitant corticotropin production.

Original languageEnglish
Pages (from-to)138-142
Number of pages5
JournalAnnals of Neurology
Volume53
Issue number1
DOIs
Publication statusPublished - Jan 1 2003

Fingerprint

Cushing Syndrome
Corticotropin-Releasing Hormone
Meningioma
Ectopic Hormones
Biological Assay
Adrenocorticotropic Hormone
High Pressure Liquid Chromatography
Hormones
Neoplasms

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Meningioma presenting with Cushing's syndrome : An unusual clinical presentation. / Pecori Giraldi, Francesca; Terreni, Maria Rosa; Andreotti, Claudia; Losa, Marco; Lanzi, Roberto; Pontiroli, Antonio E.; Cavagnini, Francesco.

In: Annals of Neurology, Vol. 53, No. 1, 01.01.2003, p. 138-142.

Research output: Contribution to journalArticle

@article{5986dbcf2ee947518a608b95ee663c4d,
title = "Meningioma presenting with Cushing's syndrome: An unusual clinical presentation",
abstract = "We report a patient with a meningioma presenting with Cushing's syndrome, an unprecedented paraneoplastic presentation. Molecular studies, bioassay, and high-performance liquid chromatography of tumor specimens demonstrated the synthesis and secretion of bioactive corticotropin-releasing hormone. To our knowledge, this appears to be the first report of a hormone-secreting meningioma and, further, the first clearly proven case of Cushing's syndrome due to ectopic corticotropin-releasing hormone secretion without concomitant corticotropin production.",
author = "{Pecori Giraldi}, Francesca and Terreni, {Maria Rosa} and Claudia Andreotti and Marco Losa and Roberto Lanzi and Pontiroli, {Antonio E.} and Francesco Cavagnini",
year = "2003",
month = "1",
day = "1",
doi = "10.1002/ana.10454",
language = "English",
volume = "53",
pages = "138--142",
journal = "Annals of Neurology",
issn = "0364-5134",
publisher = "John Wiley and Sons Inc.",
number = "1",

}

TY - JOUR

T1 - Meningioma presenting with Cushing's syndrome

T2 - An unusual clinical presentation

AU - Pecori Giraldi, Francesca

AU - Terreni, Maria Rosa

AU - Andreotti, Claudia

AU - Losa, Marco

AU - Lanzi, Roberto

AU - Pontiroli, Antonio E.

AU - Cavagnini, Francesco

PY - 2003/1/1

Y1 - 2003/1/1

N2 - We report a patient with a meningioma presenting with Cushing's syndrome, an unprecedented paraneoplastic presentation. Molecular studies, bioassay, and high-performance liquid chromatography of tumor specimens demonstrated the synthesis and secretion of bioactive corticotropin-releasing hormone. To our knowledge, this appears to be the first report of a hormone-secreting meningioma and, further, the first clearly proven case of Cushing's syndrome due to ectopic corticotropin-releasing hormone secretion without concomitant corticotropin production.

AB - We report a patient with a meningioma presenting with Cushing's syndrome, an unprecedented paraneoplastic presentation. Molecular studies, bioassay, and high-performance liquid chromatography of tumor specimens demonstrated the synthesis and secretion of bioactive corticotropin-releasing hormone. To our knowledge, this appears to be the first report of a hormone-secreting meningioma and, further, the first clearly proven case of Cushing's syndrome due to ectopic corticotropin-releasing hormone secretion without concomitant corticotropin production.

UR - http://www.scopus.com/inward/record.url?scp=0037234269&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037234269&partnerID=8YFLogxK

U2 - 10.1002/ana.10454

DO - 10.1002/ana.10454

M3 - Article

C2 - 12509860

AN - SCOPUS:0037234269

VL - 53

SP - 138

EP - 142

JO - Annals of Neurology

JF - Annals of Neurology

SN - 0364-5134

IS - 1

ER -