Meningioma presenting with Cushing's syndrome: An unusual clinical presentation

Francesca Pecori Giraldi, Maria Rosa Terreni, Claudia Andreotti, Marco Losa, Roberto Lanzi, Antonio E. Pontiroli, Francesco Cavagnini

Research output: Contribution to journalArticlepeer-review


We report a patient with a meningioma presenting with Cushing's syndrome, an unprecedented paraneoplastic presentation. Molecular studies, bioassay, and high-performance liquid chromatography of tumor specimens demonstrated the synthesis and secretion of bioactive corticotropin-releasing hormone. To our knowledge, this appears to be the first report of a hormone-secreting meningioma and, further, the first clearly proven case of Cushing's syndrome due to ectopic corticotropin-releasing hormone secretion without concomitant corticotropin production.

Original languageEnglish
Pages (from-to)138-142
Number of pages5
JournalAnnals of Neurology
Issue number1
Publication statusPublished - Jan 1 2003

ASJC Scopus subject areas

  • Neuroscience(all)


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