TY - JOUR
T1 - Meniscal scaffolds
T2 - results and indications. A systematic literature review
AU - Filardo, Giuseppe
AU - Andriolo, Luca
AU - Kon, Elizaveta
AU - de Caro, Francesca
AU - Marcacci, Maurilio
PY - 2014
Y1 - 2014
N2 - Purpose: The aim of this systematic review was to document the available clinical evidence to support meniscal scaffold implantation, analysing results and indications for the treatment of meniscal loss. Methods: The systematic review of the literature was performed searching three medical electronic databases: PubMed, Scopus, and the Cochrane Collaboration. The guidelines for preferred reporting items for systematic reviews and meta-analysis (PRISMA) were used. Relevant data were then extracted and collected in a unique database with consensus of two observers. To assess the methodological quality of the collected data, the subscales of a modified Coleman methodology score (CMS) were determined. Results: A total of 23 studies on two scaffolds (CMI®, Ivy Sports Medicine GmbH, Germany; Actifit, Orteq, United Kingdom) met the inclusion criteria and were used for the final analysis, of which more than half have been published in the last three years. Good clinical results have been documented in 613 patients, mainly young men affected by symptomatic chronic lesions, with a cumulative failure rate of 6.1 % and presence of newly formed tissue documented both at histological and MRI evaluation in most cases. However, there is a lack of comparative trials and the average study quality is low. Conclusion: An increase in publications regarding this topic has been seen recently, due to the introduction in the clinical practice of the second synthetic scaffold. Safety and positive results have been shown for both scaffolds. Although, literature lacks randomized trials at long-term follow-up to confirm real potential and most appropriate indications of meniscal scaffold implantation.
AB - Purpose: The aim of this systematic review was to document the available clinical evidence to support meniscal scaffold implantation, analysing results and indications for the treatment of meniscal loss. Methods: The systematic review of the literature was performed searching three medical electronic databases: PubMed, Scopus, and the Cochrane Collaboration. The guidelines for preferred reporting items for systematic reviews and meta-analysis (PRISMA) were used. Relevant data were then extracted and collected in a unique database with consensus of two observers. To assess the methodological quality of the collected data, the subscales of a modified Coleman methodology score (CMS) were determined. Results: A total of 23 studies on two scaffolds (CMI®, Ivy Sports Medicine GmbH, Germany; Actifit, Orteq, United Kingdom) met the inclusion criteria and were used for the final analysis, of which more than half have been published in the last three years. Good clinical results have been documented in 613 patients, mainly young men affected by symptomatic chronic lesions, with a cumulative failure rate of 6.1 % and presence of newly formed tissue documented both at histological and MRI evaluation in most cases. However, there is a lack of comparative trials and the average study quality is low. Conclusion: An increase in publications regarding this topic has been seen recently, due to the introduction in the clinical practice of the second synthetic scaffold. Safety and positive results have been shown for both scaffolds. Although, literature lacks randomized trials at long-term follow-up to confirm real potential and most appropriate indications of meniscal scaffold implantation.
KW - Cartilage
KW - Knee
KW - Meniscal substitution
KW - Meniscus
KW - Scaffold
UR - http://www.scopus.com/inward/record.url?scp=84939872655&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84939872655&partnerID=8YFLogxK
U2 - 10.1007/s00264-014-2415-x
DO - 10.1007/s00264-014-2415-x
M3 - Article
C2 - 24973973
AN - SCOPUS:84939872655
VL - 39
SP - 35
EP - 46
JO - International Orthopaedics
JF - International Orthopaedics
SN - 0341-2695
IS - 1
ER -