Menopausal hormone therapy and risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition

Konstantinos K. Tsilidis, Naomi E. Allen, Timothy J. Key, Miguel A. Sanjoaquin, Kjersti Bakken, Franco Berrino, Agnès Fournier, Eiliv Lund, Kim Overvad, Anja Olsen, Anne Tjønneland, Graham Byrnes, Veronique Chajes, Sabina Rinaldi, Marie Christine Boutron-Ruault, Francoise Clavel-Chapelon, Jenny Chang-Claude, Rudolf Kaaks, Manuela Bergmann, Heiner BoeingYvoni Koumantaki, Domenico Palli, Valeria Pala, Salvatore Panico, Rosario Tumino, Paolo Vineis, H. Bas Bueno-De-Mesquita, Carla H. Van Gils, Petra H M Peeters, Laudina Rodríguez, Carlos A. González, María José Sánchez, Maria Dolores Chirlaque, Aurelio Barricarte, Miren Dorronsoro, Kay Tee Khaw, Sheila A. Rodwell, Teresa Norat, Dora Romaguera, Elio Riboli

Research output: Contribution to journalArticlepeer-review

Abstract

Menopausal hormone therapy (HT) may influence colorectal cancer risk. A total of 136,275 postmenopausal women from the European Prospective Investigation into Cancer and Nutrition were followed for an average of 9 years, during which time 1,186 colorectal cancers were diagnosed. Hazard ratios (HR) and 95% confidence intervals (CI) were estimated using Cox proportional hazards models stratified by center and age, and adjusted for body mass index, smoking, diabetes, physical activity and alcohol consumption. Compared to never use of HT at study enrolment, current use of estrogen-only (HR, 1.02; 95% CI, 0.79-1.31) or estrogen plus progestin (HR, 0.94; 95% CI, 0.77-1.14) was not significantly associated with the risk of colorectal cancer, and these associations did not vary by recency, duration, route of administration, regimen or specific constituent of HT. Our results show no significant association of estrogen-only or estrogen plus progestin therapy with colorectal cancer risk.

Original languageEnglish
Pages (from-to)1881-1889
Number of pages9
JournalInternational Journal of Cancer
Volume128
Issue number8
DOIs
Publication statusPublished - Apr 15 2011

Keywords

  • cohort study
  • colorectal cancer
  • hormone replacement therapy

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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