Menopause induced by oophorectomy reveals a role of ovarian estrogen on the maintenance of pressure homeostasis

Giuseppe Mercuro, Sandra Zoncu, Francesca Saiu, Monica Mascia, Gian Benedetto Melis, Giuseppe M C Rosano

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: Following spontaneous menopause women show a greater increase in systolic and diastolic blood pressure than men of the same age. The aim of the present study was to assess the effect of acute ovarian hormone withdrawal and replacement on blood pressure and forearm blood flow. Methods: We studied 18 fertile middle-aged normotensive women (48±1.5 years, range 46-51 years) 1 week prior and 1 month subsequent to bilateral oophorectomy by means of 24-h blood pressure monitoring and strain-gauge venous occlusion plethysmography. Eighteen subjects who had undergone hysterectomy with ovarian sparing, matched for age and biophysical characteristics, were used as a control group. All women were free from cardiovascular risk factors or disease. Results: Oophorectomy increased the mean values of 24 h (P

Original languageEnglish
Pages (from-to)131-138
Number of pages8
JournalMaturitas
Volume47
Issue number2
DOIs
Publication statusPublished - Feb 20 2004

Keywords

  • Ambulatory BP monitoring
  • Arterial blood pressure
  • Estrogen replacement therapy
  • Ovarian failure

ASJC Scopus subject areas

  • Ageing
  • Obstetrics and Gynaecology

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