Menstrual and reproductive factors in women, genetic variation in CYP17A1, and pancreatic cancer risk in the European prospective investigation into cancer and nutrition (EPIC) cohort

Eric J. Duell, Noémie Travier, Leila Lujan-Barroso, Laure Dossus, Marie Christine Boutron-Ruault, Françoise Clavel-Chapelon, Rosario Tumino, Giovanna Masala, Vittorio Krogh, Salvatore Panico, Fulvio Ricceri, Maria Luisa Redondo, Miren Dorronsoro, Esther Molina-Montes, José M. Huerta, Aurelio Barricarte, Kay Tee Khaw, Nick J. Wareham, Naomi E. Allen, Ruth TravisPeter D. Siersema, Petra H M Peeters, Antonia Trichopoulou, Eirini Fragogeorgi, Eleni Oikonomou, Heiner Boeing, Madlen Schuetze, Federico Canzian, Annekatrin Lukanova, Anne Tjønneland, Nina Roswall, Kim Overvad, Elisabete Weiderpass, Inger Torhild Gram, Eiliv Lund, Björn Lindkvist, Dorthe Johansen, Weimin Ye, Malin Sund, Veronika Fedirko, Mazda Jenab, Dominique S. Michaud, Elio Riboli, H. Bas Bueno-De-Mesquita

Research output: Contribution to journalArticle

Abstract

Menstrual and reproductive factors and exogenous hormone use have been investigated as pancreatic cancer risk factors in case-control and cohort studies, but results have been inconsistent. We conducted a prospective examination of menstrual and reproductive factors, exogenous hormone use and pancreatic cancer risk (based on 304 cases) in 328,610 women from the EPIC cohort. Then, in a case-control study nested within the EPIC cohort, we examined 12 single nucleotide polymorphisms (SNPs) in CYP17A1 (an essential gene in sex steroid metabolism) for association with pancreatic cancer in women and men (324 cases and 353 controls). Of all factors analyzed, only younger age at menarche (

Original languageEnglish
Pages (from-to)2164-2175
Number of pages12
JournalInternational Journal of Cancer
Volume132
Issue number9
DOIs
Publication statusPublished - May 1 2013

Keywords

  • CYP17A1
  • estrogens
  • hormones
  • menstruation
  • pancreatic cancer
  • reproduction
  • women

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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  • Cite this

    Duell, E. J., Travier, N., Lujan-Barroso, L., Dossus, L., Boutron-Ruault, M. C., Clavel-Chapelon, F., Tumino, R., Masala, G., Krogh, V., Panico, S., Ricceri, F., Redondo, M. L., Dorronsoro, M., Molina-Montes, E., Huerta, J. M., Barricarte, A., Khaw, K. T., Wareham, N. J., Allen, N. E., ... Bueno-De-Mesquita, H. B. (2013). Menstrual and reproductive factors in women, genetic variation in CYP17A1, and pancreatic cancer risk in the European prospective investigation into cancer and nutrition (EPIC) cohort. International Journal of Cancer, 132(9), 2164-2175. https://doi.org/10.1002/ijc.27875