Menstrual and reproductive history and use of exogenous sex hormones and risk of thyroid cancer among women: a meta-analysis of prospective studies

Saverio Caini, Bianca Gibelli, Domenico Palli, Calogero Saieva, Massimilano Ruscica, Sara Gandini

Research output: Contribution to journalArticle

Abstract

Purpose: Thyroid cancer has a higher incidence in women than in men, and it has been hypothesized that hormonal factors may explain such disparity. We performed a meta-analysis of observational prospective studies to investigate the association between menstrual and reproductive variables and exogenous hormone use and the risk of thyroid cancer among women.

Methods: We calculated summary relative risks and 95 % confidence intervals (95 % CI) using random effect models.

Results: Overall, 5,434 thyroid cancer cases from twenty-four papers were included. Increasing age at first pregnancy/birth (SRR 1.56, 95 % CI 1.01–2.42) and hysterectomy (SRR 1.43, 95 % CI 1.15–1.78) were associated with thyroid cancer risk. Women that were in menopause at enrolment had a reduced thyroid cancer risk (SRR 0.79, 95 % CI 0.62–1.01). No other menstrual, reproductive, and hormonal variable was associated with thyroid cancer risk.

Conclusions: Menstrual and reproductive factors may play a role in the etiology of thyroid cancer, possibly through the mediation of estrogen receptors.

Original languageEnglish
Pages (from-to)511-518
Number of pages8
JournalCancer Causes and Control
Volume26
Issue number4
DOIs
Publication statusPublished - 2015

Keywords

  • Hormone use
  • Menstrual factors
  • Meta-analysis
  • Reproductive factors
  • Thyroid cancer

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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