Menstrual cycle resumption and female fertility after autologous hematopoietic stem cell transplantation for multiple sclerosis

Claudia Massarotti, Elvira Sbragia, Giacomo Boffa, Caterina Vercelli, Giovanni Bosco Zimatore, Salvatore Cottone, Jessica Frau, Annamaria Raiola, Riccardo Varaldo, Gianluigi Mancardi, Matilde Inglese, Paola Anserini

Research output: Contribution to journalArticlepeer-review

Abstract

Data on fertility after autologous hematopoietic stem cell transplantation (aHSCT) in women with multiple sclerosis (MS) are inconclusive. This study aims to report on post-aHSCT menstrual resumption in a multi-center MS-women cohort. Out of 43 women, 30 (70%) recovered menses after a mean time of 6.8 months. Older age (odds ratio (OR) = 0.5, p < 0.0001) and previous pulsed cyclophosphamide (OR = 0.44, p = 0.005) were independently associated with a reduced menstrual recovery probability. Conditioning regimens’ intensity resulted not associated with post-procedure amenorrhea. Our results highlight younger age as significantly associated with menses recovery; proper fertility counseling for MS women candidated to aHSCT both prior- and post-transplantation is therefore warranted.

Original languageEnglish
JournalMultiple Sclerosis Journal
DOIs
Publication statusAccepted/In press - 2021

Keywords

  • Aggressive multiple sclerosis
  • amenorrhea
  • autologous hematopoietic stem cell transplantation
  • fertility
  • menstrual cycle

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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