Mental adaptation to cancer: Depression and blood platelet monoamine oxidase activity in breast cancer patients

Tullio Giraldi, Maurizio De Vanna, Maria Malagoli, Guido Tuveri, Katia Sutto, Giulia Schillani, Luigi Grassi

Research output: Contribution to journalArticle

Abstract

Background: Stress and depression were reported as negative prognostic factors in breast cancer patients and monoamine oxidase (MAO) activity was considered a marker of mental suffering. Materials and Methods: MAO activity in platelets was determined in a group of newly diagnosed breast cancer patients, after the communication of diagnosis and surgery, using the Mental Adjustment to Cancer (MAC) and Hospital Anxiety and Depression scales (HADS). Results: The analysis of regression indicated that hopelessness-helplessness positively correlated with depression, anxiety and anxious preoccupation. Monoamine oxidase (MAO) activity displayed a positive regression coefficient with depression score. At follow-up, Cox analysis of survival indicated that MAO activity was a marginally significant risk factor. Conclusion: Further research in a larger group of patients may support the present results, showing that MAO activity is a biological marker of difficulties in mental adaptation to cancer and is a risk factor for survival.

Original languageEnglish
Pages (from-to)1715-1719
Number of pages5
JournalAnticancer Research
Volume27
Issue number3 B
Publication statusPublished - May 2007

Keywords

  • Blood platelets
  • Breast cancer
  • Depression
  • MAO
  • Mental adaptation to cancer
  • Monoamine oxidase

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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    Giraldi, T., De Vanna, M., Malagoli, M., Tuveri, G., Sutto, K., Schillani, G., & Grassi, L. (2007). Mental adaptation to cancer: Depression and blood platelet monoamine oxidase activity in breast cancer patients. Anticancer Research, 27(3 B), 1715-1719.