Mercurio: Studio sull'effetto promoter, concentrazione di citochine e comunicazione intercellulare nei cheratinociti umani

INTRODUCTION. Gap functional intercellular communication is an intercellular communication system that mammalians use to control cell proliferation, cell differentiation, programmed cell death or apoptosis and the adaptive responses of differentiated cells. The term interleukin was originally coined by a group of immunologists attempting to simplify and to clarify the discussion of soluble factors acting on lymphocytes. The keratinocyte. the principle epidermal cell, is a also contributor to epidermal cytokine production. Many of the currently identified cytokines are produced by keratinocytes, either constitutively or upon induction by various stimuli. The aim of our study is to evaluate if Mercury reduces the intracellular concentration of IL1-Beta and TNF, like in a previous work it was able to inhibit GJIC.