Carcinoma a cellule di Merkel e linfonodo sentinella: osservazioni su nove casi clinici.

Translated title of the contribution: Merkel cell carcinoma and sentinel lymph node dissection: nine cases report

E. Migliano, C. Monarca, M. Tedesco, M. I. Rizzo, S. Bucher

Research output: Contribution to journalArticle

Abstract

Merkel cell carcinoma (MCC) is an aggressive cutaneous-neuroendocrine neoplasia with poor prognosis and high propensity for locoregional and distant metastasis. Lack of knowledge about its biological behavior, pathogenesis, and prognostic factors, complicates the prospective evaluation. Sentinel node dissection, concomitant with radical excision of the lesion, has increased in the last few years. The suitability of this technique is linked to the MCC high tendency to spread "in primis" at locoregional nodes such as other malignancies such as cutaneous melanoma. Aim of the study is the prospective evaluation of the sentinel node dissection and of the adjuvant therapies in 9 patients MCC affected. All patients, underwent evaluation and staging of the neoplasia. Diagnosis was made by excisional biopsy and histological examination. Sentinel node dissection was performed in patients without clinical locoregional metastases (8 cases). Patients with sentinel node positive for metastasis underwent radical lymphadenectomy (3 cases). One patient affected by clinically locoregional metastases had, at once, radical lymphadenectomy. Radiotherapy and/or chemotherapy as adjuvant therapy were implemented (4 cases).

Translated title of the contributionMerkel cell carcinoma and sentinel lymph node dissection: nine cases report
Original languageItalian
Pages (from-to)28-32
Number of pages5
JournalGiornale di Chirurgia
Volume29
Issue number1-2
Publication statusPublished - Jan 2008

ASJC Scopus subject areas

  • Surgery

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