Merkel cell carcinoma arising in inguinal lymph node in a patient with von Willebrand disease after multiple blood transfusions

Renzo Boldorini, Sara Allegrini, Mauro Tognon, Umberto Miglio, Davide Rossi, Michael Pawlita, Raphael Viscidi

Research output: Contribution to journalArticlepeer-review

Abstract

Merkel cell carcinoma (MCC) is an uncommon neuroendocrine tumour of the skin; rare cases have been reported within the lymph nodes without a primary site. The detection of Merkel cell polyomavirus (MCPyV) DNA, integrated within the genome of MCC, suggests its role for the onset of this tumour. We report a case of MCC in an inguinal lymph node of a patient with Von Willebrand disease (VWD), who underwent multiple blood transfusions following haemorrhoidectomy. The diagnosis was performed on the bases of morphology and immunohistochemistry; genomic sequences of LT and VP1 regions of MCPyV were amplified from MCC using a quantitative polymerase chain reaction (qPCR) assay. High levels of MCPyV antibodies were detected in the patient's serum by ELISA method. We discuss the role of MCPyV in the development of this tumour, the use of viral DNA detection for confirming the diagnosis of MCC in unusual sites and the possibility of MCPyV transmission from blood donors.

Original languageEnglish
Pages (from-to)73-75
Number of pages3
JournalJournal of Clinical Virology
Volume60
Issue number1
DOIs
Publication statusPublished - 2014

Keywords

  • Lymph node
  • Merkel cell carcinoma (MCC)
  • Merkel cell polyomavirus (MCPyV)
  • Von Willebrand disease

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases
  • Medicine(all)

Fingerprint

Dive into the research topics of 'Merkel cell carcinoma arising in inguinal lymph node in a patient with von Willebrand disease after multiple blood transfusions'. Together they form a unique fingerprint.

Cite this