Merkel cell carcinoma of the skin. Treatment of primary, recurrent, and metastatic disease: Review of clinical cases

Paola Queirolo, Marco Gipponi, Alberto Peressini, Carmine F. Disomma, Stefania Vecchio, Edoardo Raposio, Marina Guenzi, Mario Roberto Sertoli, Erdinando Cafiero

Research output: Contribution to journalArticlepeer-review

Abstract

The clinical features of 10 cases with the adjunct of a literature review of primary neuroendocrine carcinoma of the skin (Merkel cell tumor) are reported. This cancer arises in the dermis and subcutaneous tissue of elderly individuals. Natural history is characterized by local recurrences (40%), regional lymphnodes metastases (50%), and distant metastases (60%). Surgery is the elective treatment of primary and locoregional disease and subsequent radiotherapy prevents local recurrences and prolong disease-free survival in literature reports. Chemotherapy and radiotherapy resulted in only a short-term palliative response in the metastatic setting.

Original languageEnglish
Pages (from-to)673-677
Number of pages5
JournalAnticancer Research
Volume17
Issue number1 B
Publication statusPublished - 1997

Keywords

  • Merkel cell carcinoma therapy primary disease recurrent disease metastatic disease

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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