Merkel-cell polyomavirus (MCPyV) is rarely associated to B-chronic lymphocytic leukemia (1 out of 50) samples and occurs late in the natural history of the disease

Manola Comar, Antonio Cuneo, Iva Maestri, Elisabetta Melloni, Gabriele Pozzato, Olga Soffritti, Paola Secchiero, Giorgio Zauli

Research output: Contribution to journalArticle

Abstract

Background: Previous studies have reported conflicting results on the frequency and potential pathogenetic role of Merkel-cell polyomavirus (MCPyV) in B-chronic lymphocytic leukemia (B-CLL). Objectives: To evaluate the association of MCPyV to B-CLL and to investigate the occurrence of MCPyV infection in relationship to the natural history of B-CLL. Study design: Samples of primary B-CLL peripheral blood mononuclear cells were obtained from two distinct University Hospitals of Italy from January 2010. For one B-CLL patient, it was possible to retrospectively examine the blood sample at diagnosis of B-CLL (March 2004) and several pathological tissues of cutaneous tumors occurring during the course of the disease. Results: Only one out of 50 B-CLL blood samples examined was positive for MCPyV DNA. Retrospective analysis revealed that MCPyV DNA was absent in peripheral blood sample at diagnosis, becoming present only in advanced disease stages also in tonsil tissue as well as in a biopsy of differentiated squamous cell carcinoma. Conclusions: The association with MCPyV seems to represent a rare and late event during the natural history of B-CLL.

Original languageEnglish
Pages (from-to)367-369
Number of pages3
JournalJournal of Clinical Virology
Volume55
Issue number4
DOIs
Publication statusPublished - Dec 2012

Keywords

  • B-CLL
  • MCPyV
  • Squamous cell carcinoma

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

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