Mesangial expression of intercellular adhesion molecule-1 in primary glomerulosclerosis

Antonio Dal Canton, Giorgio Fuiano, Vincenzo Sepe, Alfredo Caglioti, Soldano Ferrone

Research output: Contribution to journalArticle

Abstract

Frozen sections of renal biopsy specimens from eight patients with primary focal segmental glomerulosclerosis (FSGS) and 10 patients with membranous nephropathy (MN) were stained in immunoperoxidase with the intercellular adhesion molecule-1 (ICAM-1) monoclonal antibody (MoAb), CL203.4. ICAM-1 was expressed by mesangial cells in six patients with FSGS. On the other hand, ICAM-1 was not detected in mesangial cells in patients with MN or in the non-affected portion of tumoral kidneys used to control normal renal expression of 1CAM-1. De novo mesangial expression of ICAM-1 in FSGS suggests that sclerosis results from an inflammatory process, possibly associated with local release of cytokines.

Original languageEnglish
Pages (from-to)951-955
Number of pages5
JournalKidney International
Volume41
Issue number4
Publication statusPublished - Apr 1992

ASJC Scopus subject areas

  • Nephrology

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    Dal Canton, A., Fuiano, G., Sepe, V., Caglioti, A., & Ferrone, S. (1992). Mesangial expression of intercellular adhesion molecule-1 in primary glomerulosclerosis. Kidney International, 41(4), 951-955.