Mesangial expression of intercellular adhesion molecule-1 in primary glomerulosclerosis

Antonio Dal Canton; Giorgio Fuiano; Vincenzo Sepe; Alfredo Caglioti; Soldano Ferrone

Mesangial expression of intercellular adhesion molecule-1 in primary glomerulosclerosis

Antonio Dal Canton, Giorgio Fuiano, Vincenzo Sepe, Alfredo Caglioti, Soldano Ferrone

IRCCS Fondazione Policlinico San Matteo

Research output: Contribution to journal › Article › peer-review

Abstract

Frozen sections of renal biopsy specimens from eight patients with primary focal segmental glomerulosclerosis (FSGS) and 10 patients with membranous nephropathy (MN) were stained in immunoperoxidase with the intercellular adhesion molecule-1 (ICAM-1) monoclonal antibody (MoAb), CL203.4. ICAM-1 was expressed by mesangial cells in six patients with FSGS. On the other hand, ICAM-1 was not detected in mesangial cells in patients with MN or in the non-affected portion of tumoral kidneys used to control normal renal expression of 1CAM-1. De novo mesangial expression of ICAM-1 in FSGS suggests that sclerosis results from an inflammatory process, possibly associated with local release of cytokines.

Original language	English
Pages (from-to)	951-955
Number of pages	5
Journal	Kidney International
Volume	41
Issue number	4
Publication status	Published - Apr 1992

ASJC Scopus subject areas

Nephrology

Cite this

@article{a88ccba464f044c89b640453fa83389f,

title = "Mesangial expression of intercellular adhesion molecule-1 in primary glomerulosclerosis",

abstract = "Frozen sections of renal biopsy specimens from eight patients with primary focal segmental glomerulosclerosis (FSGS) and 10 patients with membranous nephropathy (MN) were stained in immunoperoxidase with the intercellular adhesion molecule-1 (ICAM-1) monoclonal antibody (MoAb), CL203.4. ICAM-1 was expressed by mesangial cells in six patients with FSGS. On the other hand, ICAM-1 was not detected in mesangial cells in patients with MN or in the non-affected portion of tumoral kidneys used to control normal renal expression of 1CAM-1. De novo mesangial expression of ICAM-1 in FSGS suggests that sclerosis results from an inflammatory process, possibly associated with local release of cytokines.",

author = "{Dal Canton}, Antonio and Giorgio Fuiano and Vincenzo Sepe and Alfredo Caglioti and Soldano Ferrone",

year = "1992",

month = apr,

language = "English",

volume = "41",

pages = "951--955",

journal = "Kidney International",

issn = "0085-2538",

publisher = "Nature Publishing Group",

number = "4",

}

TY - JOUR

T1 - Mesangial expression of intercellular adhesion molecule-1 in primary glomerulosclerosis

AU - Dal Canton, Antonio

AU - Fuiano, Giorgio

AU - Sepe, Vincenzo

AU - Caglioti, Alfredo

AU - Ferrone, Soldano

PY - 1992/4

Y1 - 1992/4

N2 - Frozen sections of renal biopsy specimens from eight patients with primary focal segmental glomerulosclerosis (FSGS) and 10 patients with membranous nephropathy (MN) were stained in immunoperoxidase with the intercellular adhesion molecule-1 (ICAM-1) monoclonal antibody (MoAb), CL203.4. ICAM-1 was expressed by mesangial cells in six patients with FSGS. On the other hand, ICAM-1 was not detected in mesangial cells in patients with MN or in the non-affected portion of tumoral kidneys used to control normal renal expression of 1CAM-1. De novo mesangial expression of ICAM-1 in FSGS suggests that sclerosis results from an inflammatory process, possibly associated with local release of cytokines.

AB - Frozen sections of renal biopsy specimens from eight patients with primary focal segmental glomerulosclerosis (FSGS) and 10 patients with membranous nephropathy (MN) were stained in immunoperoxidase with the intercellular adhesion molecule-1 (ICAM-1) monoclonal antibody (MoAb), CL203.4. ICAM-1 was expressed by mesangial cells in six patients with FSGS. On the other hand, ICAM-1 was not detected in mesangial cells in patients with MN or in the non-affected portion of tumoral kidneys used to control normal renal expression of 1CAM-1. De novo mesangial expression of ICAM-1 in FSGS suggests that sclerosis results from an inflammatory process, possibly associated with local release of cytokines.

UR - http://www.scopus.com/inward/record.url?scp=0026596587&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026596587&partnerID=8YFLogxK

M3 - Article

C2 - 1381006

AN - SCOPUS:0026596587

VL - 41

SP - 951

EP - 955

JO - Kidney International

JF - Kidney International

SN - 0085-2538

IS - 4

ER -

Mesangial expression of intercellular adhesion molecule-1 in primary glomerulosclerosis

Abstract

ASJC Scopus subject areas

Other files and links

Fingerprint

Cite this