Mesenchymal chondrosarcoma. An analysis of patients treated at a single institution

Marilena Cesari, Franco Bertoni, Patrizia Bacchini, Mario Mercuri, Emanuela Palmerini, Stefano Ferrari

Research output: Contribution to journalArticle

Abstract

Background: We analyzed clinical and treatment-related factors influencing the outcome of patients with mesenchymal chondrosarcoma (MC). Twenty-six patients (median age, 31 years) were identified using the Tumor Center and Chemotherapy Department database of the study institute. Methods: Patients received surgery (24 patients) and/or radiotherapy (5 patients), and chemotherapy (12 patients). Results: After a median follow-up of 48 months (7-237 months) 10 patients were alive. The 10-year overall survival (OS) was 27% in those who achieved complete surgical remission and 0% in those who did not (P = 0.0007). A worse 10-year probability of OS was observed in patients who were metastatic at presentation (metastatic 0%, localized 31%, P = 0.02), in patients with soft tissue MC (soft tissue MC 0%, bone MC 29%, P = 0.06) and in hemangiopericytoma-like MC (hemangiopericytoma-like MC 0%, Ewing's-like MC 33.5%, P = 0.9). In those patients who achieved complete surgical remission, the 10-year DFS was 76% for those who received chemotherapy and 17% for those who did not (P = 0.008). Conclusions: Our experience confirmed the importance of complete surgical remission in MC treatment and suggests that the addition of chemotherapy should offer a benefit in terms of DFS. Due to the rarity of MC, multicentrer studies are needed to identify the most active chemotherapy regimen.

Original languageEnglish
Pages (from-to)423-427
Number of pages5
JournalTumori
Volume93
Issue number5
Publication statusPublished - Sep 2007

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Keywords

  • Chemotherapy
  • Mesenchymal chondrosarcoma
  • Radiotherapy

ASJC Scopus subject areas

  • Cancer Research

Cite this

Cesari, M., Bertoni, F., Bacchini, P., Mercuri, M., Palmerini, E., & Ferrari, S. (2007). Mesenchymal chondrosarcoma. An analysis of patients treated at a single institution. Tumori, 93(5), 423-427.