Mesenchymal stem cells as adjuvant therapy for limb lengthening in achondroplasia

Antonio Memeo, Fabio Verdoni, Caterina Ingraffia, Laura Rossi, Leopoldo Pedretti, Raffaele D D'Amato, Laura Peretto, Giuseppe V Mineo

Research output: Contribution to journalArticle

Abstract

Staged leg lengthening allows achondroplastic dwarfs to reach nearly normal height, but it takes long periods of external fixation and it can be burdened by delayed unions. Between 2009 and 2013, eight achondroplastic dwarfs showed delayed unions in the callus formation during femoral lengthening stages in our institute. We performed in-situ injections of bone marrow-derived stem cell concentrates. Patients underwent monthly clinical and radiographic assessment for determination of the healing rate. All eight patients showed an improvement in the regenerated bone, with an average healing index of 23.1 days/cm (range: 18.7-23.8 days/cm). The complete recovery of the delayed consolidation took on an average of 5.2 months (range: 2-10 months). The use of cellular therapy in these patients could represent an innovative application.

Original languageEnglish
JournalJournal of Pediatric Orthopaedics Part B
DOIs
Publication statusE-pub ahead of print - Nov 15 2018
Externally publishedYes

Fingerprint

Achondroplasia
Mesenchymal Stromal Cells
Extremities
Bony Callus
Thigh
Leg
Stem Cells
Therapeutics
Bone Marrow
Bone and Bones
Injections

Cite this

Mesenchymal stem cells as adjuvant therapy for limb lengthening in achondroplasia. / Memeo, Antonio; Verdoni, Fabio; Ingraffia, Caterina; Rossi, Laura; Pedretti, Leopoldo; D'Amato, Raffaele D; Peretto, Laura; Mineo, Giuseppe V.

In: Journal of Pediatric Orthopaedics Part B, 15.11.2018.

Research output: Contribution to journalArticle

Memeo, Antonio ; Verdoni, Fabio ; Ingraffia, Caterina ; Rossi, Laura ; Pedretti, Leopoldo ; D'Amato, Raffaele D ; Peretto, Laura ; Mineo, Giuseppe V. / Mesenchymal stem cells as adjuvant therapy for limb lengthening in achondroplasia. In: Journal of Pediatric Orthopaedics Part B. 2018.
@article{853cc46a056046cba7c6a93c0f81b880,
title = "Mesenchymal stem cells as adjuvant therapy for limb lengthening in achondroplasia",
abstract = "Staged leg lengthening allows achondroplastic dwarfs to reach nearly normal height, but it takes long periods of external fixation and it can be burdened by delayed unions. Between 2009 and 2013, eight achondroplastic dwarfs showed delayed unions in the callus formation during femoral lengthening stages in our institute. We performed in-situ injections of bone marrow-derived stem cell concentrates. Patients underwent monthly clinical and radiographic assessment for determination of the healing rate. All eight patients showed an improvement in the regenerated bone, with an average healing index of 23.1 days/cm (range: 18.7-23.8 days/cm). The complete recovery of the delayed consolidation took on an average of 5.2 months (range: 2-10 months). The use of cellular therapy in these patients could represent an innovative application.",
author = "Antonio Memeo and Fabio Verdoni and Caterina Ingraffia and Laura Rossi and Leopoldo Pedretti and D'Amato, {Raffaele D} and Laura Peretto and Mineo, {Giuseppe V}",
year = "2018",
month = "11",
day = "15",
doi = "10.1097/BPB.0000000000000571",
language = "English",
journal = "Journal of Pediatric Orthopaedics Part B",
issn = "1060-152X",
publisher = "Lippincott Williams and Wilkins",

}

TY - JOUR

T1 - Mesenchymal stem cells as adjuvant therapy for limb lengthening in achondroplasia

AU - Memeo, Antonio

AU - Verdoni, Fabio

AU - Ingraffia, Caterina

AU - Rossi, Laura

AU - Pedretti, Leopoldo

AU - D'Amato, Raffaele D

AU - Peretto, Laura

AU - Mineo, Giuseppe V

PY - 2018/11/15

Y1 - 2018/11/15

N2 - Staged leg lengthening allows achondroplastic dwarfs to reach nearly normal height, but it takes long periods of external fixation and it can be burdened by delayed unions. Between 2009 and 2013, eight achondroplastic dwarfs showed delayed unions in the callus formation during femoral lengthening stages in our institute. We performed in-situ injections of bone marrow-derived stem cell concentrates. Patients underwent monthly clinical and radiographic assessment for determination of the healing rate. All eight patients showed an improvement in the regenerated bone, with an average healing index of 23.1 days/cm (range: 18.7-23.8 days/cm). The complete recovery of the delayed consolidation took on an average of 5.2 months (range: 2-10 months). The use of cellular therapy in these patients could represent an innovative application.

AB - Staged leg lengthening allows achondroplastic dwarfs to reach nearly normal height, but it takes long periods of external fixation and it can be burdened by delayed unions. Between 2009 and 2013, eight achondroplastic dwarfs showed delayed unions in the callus formation during femoral lengthening stages in our institute. We performed in-situ injections of bone marrow-derived stem cell concentrates. Patients underwent monthly clinical and radiographic assessment for determination of the healing rate. All eight patients showed an improvement in the regenerated bone, with an average healing index of 23.1 days/cm (range: 18.7-23.8 days/cm). The complete recovery of the delayed consolidation took on an average of 5.2 months (range: 2-10 months). The use of cellular therapy in these patients could represent an innovative application.

U2 - 10.1097/BPB.0000000000000571

DO - 10.1097/BPB.0000000000000571

M3 - Article

JO - Journal of Pediatric Orthopaedics Part B

JF - Journal of Pediatric Orthopaedics Part B

SN - 1060-152X

ER -