Mesenchymal stem cells as adjuvant therapy for limb lengthening in achondroplasia

Antonio Memeo, Fabio Verdoni, Caterina Ingraffia, Laura Rossi, Leopoldo Pedretti, Raffaele D D'Amato, Laura Peretto, Giuseppe V Mineo

Research output: Contribution to journalArticle

Abstract

Staged leg lengthening allows achondroplastic dwarfs to reach nearly normal height, but it takes long periods of external fixation and it can be burdened by delayed unions. Between 2009 and 2013, eight achondroplastic dwarfs showed delayed unions in the callus formation during femoral lengthening stages in our institute. We performed in-situ injections of bone marrow-derived stem cell concentrates. Patients underwent monthly clinical and radiographic assessment for determination of the healing rate. All eight patients showed an improvement in the regenerated bone, with an average healing index of 23.1 days/cm (range: 18.7-23.8 days/cm). The complete recovery of the delayed consolidation took on an average of 5.2 months (range: 2-10 months). The use of cellular therapy in these patients could represent an innovative application.

Original languageEnglish
Pages (from-to)221-227
Number of pages7
JournalJournal of Pediatric Orthopaedics Part B
Volume28
Issue number3
Early online dateNov 15 2018
DOIs
Publication statusPublished - 2019
Externally publishedYes

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Memeo, A., Verdoni, F., Ingraffia, C., Rossi, L., Pedretti, L., D'Amato, R. D., Peretto, L., & Mineo, G. V. (2019). Mesenchymal stem cells as adjuvant therapy for limb lengthening in achondroplasia. Journal of Pediatric Orthopaedics Part B, 28(3), 221-227. https://doi.org/10.1097/BPB.0000000000000571