Mesenchymal stem cells as feeder cells for pancreatic islet transplants

Valeria Sordi, Lorenzo Piemonti

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Allogeneic islet transplantation serves as a source of insulin-secreting beta-cells for the maintenance of normal glucose levels and treatment of diabetes. However, limited availability of islets, high rates of islet graft failure, and the need for life-long non-specific immunosuppressive therapy are major obstacles to the widespread application of this therapeutic approach. To overcome these problems, pancreatic islet transplantation was recently suggested as a potential target of the "therapeutic plasticity" of adult stem cells. In fact, new results suggest that stem/precursor cells, and mesenchymal stem cells in particular, co-transplanted with islets can promote tissue engraftment and beta-cell survival via bystander mechanisms, mainly exerted by creating a milieu of cytoprotective and immunomodulatory molecules. This evidence consistently challenges the limited view that stem/precursor cells work exclusively through beta-cell replacement in diabetes therapy. It proposes that stem cells also act as "feeder" cells for islets, and supporter of graft protection, tissue revascularization, and immune acceptance. This article reviews the experience of using stem cell co-transplantation as strategy to improve islet transplantation. It highlights that comprehension of the mechanisms involved will help to identify new molecular targets and promote development of new pharmacological strategies to treat type 1 and type 2 diabetes patients.

Original languageEnglish
JournalThe review of diabetic studies : RDS
Volume7
Issue number2
DOIs
Publication statusPublished - Jun 2010

Fingerprint

Feeder Cells
Mesenchymal Stromal Cells
Islets of Langerhans
Islets of Langerhans Transplantation
Transplants
Stem Cells
Therapeutics
Adult Stem Cells
Homologous Transplantation
Insulin-Secreting Cells
Stem Cell Transplantation
Immunosuppressive Agents
Type 1 Diabetes Mellitus
Type 2 Diabetes Mellitus
Cell Survival
Maintenance
Pharmacology
Glucose

Keywords

  • Bone marrow
  • Co-transplantation
  • Feeder
  • Immunomodulation
  • Islet
  • Revascularization
  • Stem cell

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Internal Medicine

Cite this

Mesenchymal stem cells as feeder cells for pancreatic islet transplants. / Sordi, Valeria; Piemonti, Lorenzo.

In: The review of diabetic studies : RDS, Vol. 7, No. 2, 06.2010.

Research output: Contribution to journalArticle

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