TY - JOUR
T1 - Mesenchymal stem cells for tendon healing
T2 - What is on the horizon?
AU - Veronesi, Francesca
AU - Salamanna, Francesca
AU - Tschon, Matilde
AU - Maglio, Melania
AU - Nicoli Aldini, Nicolo
AU - Fini, Milena
PY - 2016
Y1 - 2016
N2 - Tendon injuries are a noteworthy morbidity but at present there are few effective scientifically proven treatments. In recent decades, a number of new strategies including tissue engineering with mesenchymal stem cells (MSCs) have been proposed to enhance tendon healing. Although MSCs are an interesting and promising approach, many questions regarding their use in tendon repair remain unanswered. This descriptive overview of the literature of the last decade explores the in vivo studies on tendon healing, in small and large animal models, which used MSCs harvested from different tissues, and the state of the art in clinical applications. It was observed that there are still doubts about the optimum amount of MSCs to use and their source and the type of scaffolds to deliver the cells. Thus, further studies are needed to determine the best protocol for MSC use in tendon healing.
AB - Tendon injuries are a noteworthy morbidity but at present there are few effective scientifically proven treatments. In recent decades, a number of new strategies including tissue engineering with mesenchymal stem cells (MSCs) have been proposed to enhance tendon healing. Although MSCs are an interesting and promising approach, many questions regarding their use in tendon repair remain unanswered. This descriptive overview of the literature of the last decade explores the in vivo studies on tendon healing, in small and large animal models, which used MSCs harvested from different tissues, and the state of the art in clinical applications. It was observed that there are still doubts about the optimum amount of MSCs to use and their source and the type of scaffolds to deliver the cells. Thus, further studies are needed to determine the best protocol for MSC use in tendon healing.
KW - Animal models
KW - Clinical trials
KW - Mesenchymal stem cells
KW - Regenerative medicine
KW - Tendon injuries
KW - Tissue engineering
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U2 - 10.1002/term.2209
DO - 10.1002/term.2209
M3 - Article
AN - SCOPUS:84985992338
JO - Journal of Tissue Engineering and Regenerative Medicine
JF - Journal of Tissue Engineering and Regenerative Medicine
SN - 1932-6254
ER -