Mesenchymal stem cells from the Wharton's jelly of the human umbilical cord: Biological properties and therapeutic potential

Luigi Marino, Maria Antonietta Castaldi, Rosa Rosamilio, Enrico Ragni, Rosa Vitolo, Caterina Fulgione, Salvatore Giovanni Castaldi, Bianca Serio, Rosario Bianco, Maurizio Guida, Carmine Selleri

Research output: Contribution to journalReview article

Abstract

Wharton's jelly mesenchymal stem cells (WJ-MSCs) are a class of stem cells with high differentiative potential, an immuno-privileged status and easy access for collection, which raise no legal or ethical issues. WJ-MSCs exhibit several features of embryonic stem cells, both in the phenotypic and genetic aspects, with only a few differences, such as a shorter doubling time and a more extensive ex vivo expansion capacity. WJ-MSCs have immunomodulatory properties, involving both innate and adaptive immune responses. This review focuses on the role of WJ-MSCs in the management of graft-versus-host disease (GvHD), a life-threatening complication of the allogenic transplantation of hematopoietic stem cells. Different studies documented the beneficial effect of the infusion of WJ-MSCs, even when not fully HLA identical, in patients with severe GvHD, refractory to standard treatment. Finally, we summarized current ongoing clinical trials with WJ-MSCs and their potential in regenerative medicine.

Original languageEnglish
Pages (from-to)218-226
Number of pages9
JournalInternational Journal of Stem Cells
Volume12
Issue number2
DOIs
Publication statusPublished - Jan 1 2019

Fingerprint

Wharton Jelly
Umbilical Cord
Mesenchymal Stromal Cells
Graft vs Host Disease
Therapeutics
Regenerative Medicine
Homologous Transplantation
Adaptive Immunity
Embryonic Stem Cells
Hematopoietic Stem Cells
Innate Immunity
Ethics
Stem Cells
Clinical Trials

Keywords

  • GvHD
  • Human umbilical cord blood
  • Immunomodulation
  • Mesenchymal stem cells
  • WJ-MSCs

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

Cite this

Mesenchymal stem cells from the Wharton's jelly of the human umbilical cord : Biological properties and therapeutic potential. / Marino, Luigi; Castaldi, Maria Antonietta; Rosamilio, Rosa; Ragni, Enrico; Vitolo, Rosa; Fulgione, Caterina; Castaldi, Salvatore Giovanni; Serio, Bianca; Bianco, Rosario; Guida, Maurizio; Selleri, Carmine.

In: International Journal of Stem Cells, Vol. 12, No. 2, 01.01.2019, p. 218-226.

Research output: Contribution to journalReview article

Marino, L, Castaldi, MA, Rosamilio, R, Ragni, E, Vitolo, R, Fulgione, C, Castaldi, SG, Serio, B, Bianco, R, Guida, M & Selleri, C 2019, 'Mesenchymal stem cells from the Wharton's jelly of the human umbilical cord: Biological properties and therapeutic potential', International Journal of Stem Cells, vol. 12, no. 2, pp. 218-226. https://doi.org/10.15283/ijsc18034
Marino, Luigi ; Castaldi, Maria Antonietta ; Rosamilio, Rosa ; Ragni, Enrico ; Vitolo, Rosa ; Fulgione, Caterina ; Castaldi, Salvatore Giovanni ; Serio, Bianca ; Bianco, Rosario ; Guida, Maurizio ; Selleri, Carmine. / Mesenchymal stem cells from the Wharton's jelly of the human umbilical cord : Biological properties and therapeutic potential. In: International Journal of Stem Cells. 2019 ; Vol. 12, No. 2. pp. 218-226.
@article{c4a2eab860af42aa9f32d414178e7712,
title = "Mesenchymal stem cells from the Wharton's jelly of the human umbilical cord: Biological properties and therapeutic potential",
abstract = "Wharton's jelly mesenchymal stem cells (WJ-MSCs) are a class of stem cells with high differentiative potential, an immuno-privileged status and easy access for collection, which raise no legal or ethical issues. WJ-MSCs exhibit several features of embryonic stem cells, both in the phenotypic and genetic aspects, with only a few differences, such as a shorter doubling time and a more extensive ex vivo expansion capacity. WJ-MSCs have immunomodulatory properties, involving both innate and adaptive immune responses. This review focuses on the role of WJ-MSCs in the management of graft-versus-host disease (GvHD), a life-threatening complication of the allogenic transplantation of hematopoietic stem cells. Different studies documented the beneficial effect of the infusion of WJ-MSCs, even when not fully HLA identical, in patients with severe GvHD, refractory to standard treatment. Finally, we summarized current ongoing clinical trials with WJ-MSCs and their potential in regenerative medicine.",
keywords = "GvHD, Human umbilical cord blood, Immunomodulation, Mesenchymal stem cells, WJ-MSCs",
author = "Luigi Marino and Castaldi, {Maria Antonietta} and Rosa Rosamilio and Enrico Ragni and Rosa Vitolo and Caterina Fulgione and Castaldi, {Salvatore Giovanni} and Bianca Serio and Rosario Bianco and Maurizio Guida and Carmine Selleri",
year = "2019",
month = "1",
day = "1",
doi = "10.15283/ijsc18034",
language = "English",
volume = "12",
pages = "218--226",
journal = "International Journal of Stem Cells",
issn = "2005-3606",
publisher = "Korean Society for Stem Cell Research",
number = "2",

}

TY - JOUR

T1 - Mesenchymal stem cells from the Wharton's jelly of the human umbilical cord

T2 - Biological properties and therapeutic potential

AU - Marino, Luigi

AU - Castaldi, Maria Antonietta

AU - Rosamilio, Rosa

AU - Ragni, Enrico

AU - Vitolo, Rosa

AU - Fulgione, Caterina

AU - Castaldi, Salvatore Giovanni

AU - Serio, Bianca

AU - Bianco, Rosario

AU - Guida, Maurizio

AU - Selleri, Carmine

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Wharton's jelly mesenchymal stem cells (WJ-MSCs) are a class of stem cells with high differentiative potential, an immuno-privileged status and easy access for collection, which raise no legal or ethical issues. WJ-MSCs exhibit several features of embryonic stem cells, both in the phenotypic and genetic aspects, with only a few differences, such as a shorter doubling time and a more extensive ex vivo expansion capacity. WJ-MSCs have immunomodulatory properties, involving both innate and adaptive immune responses. This review focuses on the role of WJ-MSCs in the management of graft-versus-host disease (GvHD), a life-threatening complication of the allogenic transplantation of hematopoietic stem cells. Different studies documented the beneficial effect of the infusion of WJ-MSCs, even when not fully HLA identical, in patients with severe GvHD, refractory to standard treatment. Finally, we summarized current ongoing clinical trials with WJ-MSCs and their potential in regenerative medicine.

AB - Wharton's jelly mesenchymal stem cells (WJ-MSCs) are a class of stem cells with high differentiative potential, an immuno-privileged status and easy access for collection, which raise no legal or ethical issues. WJ-MSCs exhibit several features of embryonic stem cells, both in the phenotypic and genetic aspects, with only a few differences, such as a shorter doubling time and a more extensive ex vivo expansion capacity. WJ-MSCs have immunomodulatory properties, involving both innate and adaptive immune responses. This review focuses on the role of WJ-MSCs in the management of graft-versus-host disease (GvHD), a life-threatening complication of the allogenic transplantation of hematopoietic stem cells. Different studies documented the beneficial effect of the infusion of WJ-MSCs, even when not fully HLA identical, in patients with severe GvHD, refractory to standard treatment. Finally, we summarized current ongoing clinical trials with WJ-MSCs and their potential in regenerative medicine.

KW - GvHD

KW - Human umbilical cord blood

KW - Immunomodulation

KW - Mesenchymal stem cells

KW - WJ-MSCs

UR - http://www.scopus.com/inward/record.url?scp=85071441696&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85071441696&partnerID=8YFLogxK

U2 - 10.15283/ijsc18034

DO - 10.15283/ijsc18034

M3 - Review article

AN - SCOPUS:85071441696

VL - 12

SP - 218

EP - 226

JO - International Journal of Stem Cells

JF - International Journal of Stem Cells

SN - 2005-3606

IS - 2

ER -