Mesenchymal stem cells

Potential for therapy and treatment of chronic non-healing skin wounds

Giovanni Marfia, Stefania Elena Navone, Clara Di Vito, Nicola Ughi, Silvia Tabano, Monica Miozzo, Carlo Tremolada, Gianni Bolla, Chiara Crotti, Francesca Ingegnoli, Paolo Rampini, Laura Riboni, Roberta Gualtierotti, Rolando Campanella

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Wound healing is a complex physiological process including overlapping phases (hemostatic/inflammatory, proliferating and remodeling phases). Every alteration in this mechanism might lead to pathological conditions of different medical relevance. Treatments for chronic nonhealing wounds are expensive because reiterative treatments are needed. Regenerative medicine and in particular mesenchymal stem cells approach is emerging as new potential clinical application in wound healing. In the past decades, advance in the understanding of molecular mechanisms underlying wound healing process has led to extensive topical administration of growth factors as part of wound care. Currently, no definitive treatment is available and the research on optimal wound care depends upon the efficacy and cost-benefit of emerging therapies. Here we provide an overview on the novel approaches through stem cell therapy to improve cutaneous wound healing, with a focus on diabetic wounds and Systemic Sclerosis-associated ulcers, which are particularly challenging. Current and future treatment approaches are discussed with an emphasis on recent advances.

Original languageEnglish
Pages (from-to)183-206
Number of pages24
JournalOrganogenesis
Volume11
Issue number4
DOIs
Publication statusPublished - Jan 1 2015

Fingerprint

Cell- and Tissue-Based Therapy
Stem cells
Mesenchymal Stromal Cells
Skin
Wound Healing
Wounds and Injuries
Physiological Phenomena
Therapeutics
Topical Administration
Regenerative Medicine
Systemic Scleroderma
Costs
Hemostatics
Ulcer
Cost-Benefit Analysis
Intercellular Signaling Peptides and Proteins
Stem Cells
Research

Keywords

  • Adipose stem cells
  • Autoimmune diseases
  • Diabetes
  • Mesenchymal stem cells
  • Systemic sclerosis
  • Ulcer
  • Wound

ASJC Scopus subject areas

  • Developmental Biology
  • Embryology
  • Transplantation
  • Biomedical Engineering

Cite this

Mesenchymal stem cells : Potential for therapy and treatment of chronic non-healing skin wounds. / Marfia, Giovanni; Navone, Stefania Elena; Di Vito, Clara; Ughi, Nicola; Tabano, Silvia; Miozzo, Monica; Tremolada, Carlo; Bolla, Gianni; Crotti, Chiara; Ingegnoli, Francesca; Rampini, Paolo; Riboni, Laura; Gualtierotti, Roberta; Campanella, Rolando.

In: Organogenesis, Vol. 11, No. 4, 01.01.2015, p. 183-206.

Research output: Contribution to journalArticle

Marfia, G, Navone, SE, Di Vito, C, Ughi, N, Tabano, S, Miozzo, M, Tremolada, C, Bolla, G, Crotti, C, Ingegnoli, F, Rampini, P, Riboni, L, Gualtierotti, R & Campanella, R 2015, 'Mesenchymal stem cells: Potential for therapy and treatment of chronic non-healing skin wounds', Organogenesis, vol. 11, no. 4, pp. 183-206. https://doi.org/10.1080/15476278.2015.1126018
Marfia, Giovanni ; Navone, Stefania Elena ; Di Vito, Clara ; Ughi, Nicola ; Tabano, Silvia ; Miozzo, Monica ; Tremolada, Carlo ; Bolla, Gianni ; Crotti, Chiara ; Ingegnoli, Francesca ; Rampini, Paolo ; Riboni, Laura ; Gualtierotti, Roberta ; Campanella, Rolando. / Mesenchymal stem cells : Potential for therapy and treatment of chronic non-healing skin wounds. In: Organogenesis. 2015 ; Vol. 11, No. 4. pp. 183-206.
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