Mesenchymal stromal cells

A novel and effective strategy for facilitating engraftment and accelerating hematopoietic recovery after transplantation?

M. E. Bernardo, A. M. Cometa, F. Locatelli

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

MSCs are multipotent cells that can be isolated from several human tissues and expanded ex vivo for clinical use. They comprise a heterogeneous population of cells, which, through production of growth factors, cell-to-cell interactions and secretion of matrix proteins, has a role in the regulation of hematopoiesis. In recent years, several experimental studies have shown that MSCs are endowed with immunomodulatory properties and with the capacity to promote graft survival in animal models. In view of these properties, MSCs have been tested in pilot studies aimed at preventing/treating graft rejection and at accelerating recovery after hematopoietic cell transplantation (HCT). The available clinical evidence deriving from these studies indicates that MSC infusion is safe and promising in terms of capacity of preventing graft failure. More debated is the effect of MSCs for what concerns their capacity of accelerating hematopoietic reconstitution after HCT. Whether the favorable effect of MSCs largely depends on the type of transplantation remains also a field of future investigation. Moreover, future researches should be oriented to gain more insights on MSC biological and functional mechanisms relevant for exploiting their use in the modulation of alloreactivity and in the promotion of hematopoietic reconstitution.

Original languageEnglish
Pages (from-to)323-329
Number of pages7
JournalBone Marrow Transplantation
Volume47
Issue number3
DOIs
Publication statusPublished - Mar 2012

Fingerprint

Cell Transplantation
Mesenchymal Stromal Cells
Transplantation
Hematopoiesis
Graft Rejection
Graft Survival
Cell Communication
Intercellular Signaling Peptides and Proteins
Animal Models
Transplants
Research
Population
Proteins

Keywords

  • cellular therapy
  • hematopoietic engraftment
  • hematopoietic stem cells
  • immune modulation
  • mesenchymal stromal cells

ASJC Scopus subject areas

  • Hematology
  • Transplantation

Cite this

Mesenchymal stromal cells : A novel and effective strategy for facilitating engraftment and accelerating hematopoietic recovery after transplantation? / Bernardo, M. E.; Cometa, A. M.; Locatelli, F.

In: Bone Marrow Transplantation, Vol. 47, No. 3, 03.2012, p. 323-329.

Research output: Contribution to journalArticle

@article{275762cbe7dd45988436a305a7516010,
title = "Mesenchymal stromal cells: A novel and effective strategy for facilitating engraftment and accelerating hematopoietic recovery after transplantation?",
abstract = "MSCs are multipotent cells that can be isolated from several human tissues and expanded ex vivo for clinical use. They comprise a heterogeneous population of cells, which, through production of growth factors, cell-to-cell interactions and secretion of matrix proteins, has a role in the regulation of hematopoiesis. In recent years, several experimental studies have shown that MSCs are endowed with immunomodulatory properties and with the capacity to promote graft survival in animal models. In view of these properties, MSCs have been tested in pilot studies aimed at preventing/treating graft rejection and at accelerating recovery after hematopoietic cell transplantation (HCT). The available clinical evidence deriving from these studies indicates that MSC infusion is safe and promising in terms of capacity of preventing graft failure. More debated is the effect of MSCs for what concerns their capacity of accelerating hematopoietic reconstitution after HCT. Whether the favorable effect of MSCs largely depends on the type of transplantation remains also a field of future investigation. Moreover, future researches should be oriented to gain more insights on MSC biological and functional mechanisms relevant for exploiting their use in the modulation of alloreactivity and in the promotion of hematopoietic reconstitution.",
keywords = "cellular therapy, hematopoietic engraftment, hematopoietic stem cells, immune modulation, mesenchymal stromal cells",
author = "Bernardo, {M. E.} and Cometa, {A. M.} and F. Locatelli",
year = "2012",
month = "3",
doi = "10.1038/bmt.2011.102",
language = "English",
volume = "47",
pages = "323--329",
journal = "Bone Marrow Transplantation",
issn = "0268-3369",
publisher = "Nature Publishing Group",
number = "3",

}

TY - JOUR

T1 - Mesenchymal stromal cells

T2 - A novel and effective strategy for facilitating engraftment and accelerating hematopoietic recovery after transplantation?

AU - Bernardo, M. E.

AU - Cometa, A. M.

AU - Locatelli, F.

PY - 2012/3

Y1 - 2012/3

N2 - MSCs are multipotent cells that can be isolated from several human tissues and expanded ex vivo for clinical use. They comprise a heterogeneous population of cells, which, through production of growth factors, cell-to-cell interactions and secretion of matrix proteins, has a role in the regulation of hematopoiesis. In recent years, several experimental studies have shown that MSCs are endowed with immunomodulatory properties and with the capacity to promote graft survival in animal models. In view of these properties, MSCs have been tested in pilot studies aimed at preventing/treating graft rejection and at accelerating recovery after hematopoietic cell transplantation (HCT). The available clinical evidence deriving from these studies indicates that MSC infusion is safe and promising in terms of capacity of preventing graft failure. More debated is the effect of MSCs for what concerns their capacity of accelerating hematopoietic reconstitution after HCT. Whether the favorable effect of MSCs largely depends on the type of transplantation remains also a field of future investigation. Moreover, future researches should be oriented to gain more insights on MSC biological and functional mechanisms relevant for exploiting their use in the modulation of alloreactivity and in the promotion of hematopoietic reconstitution.

AB - MSCs are multipotent cells that can be isolated from several human tissues and expanded ex vivo for clinical use. They comprise a heterogeneous population of cells, which, through production of growth factors, cell-to-cell interactions and secretion of matrix proteins, has a role in the regulation of hematopoiesis. In recent years, several experimental studies have shown that MSCs are endowed with immunomodulatory properties and with the capacity to promote graft survival in animal models. In view of these properties, MSCs have been tested in pilot studies aimed at preventing/treating graft rejection and at accelerating recovery after hematopoietic cell transplantation (HCT). The available clinical evidence deriving from these studies indicates that MSC infusion is safe and promising in terms of capacity of preventing graft failure. More debated is the effect of MSCs for what concerns their capacity of accelerating hematopoietic reconstitution after HCT. Whether the favorable effect of MSCs largely depends on the type of transplantation remains also a field of future investigation. Moreover, future researches should be oriented to gain more insights on MSC biological and functional mechanisms relevant for exploiting their use in the modulation of alloreactivity and in the promotion of hematopoietic reconstitution.

KW - cellular therapy

KW - hematopoietic engraftment

KW - hematopoietic stem cells

KW - immune modulation

KW - mesenchymal stromal cells

UR - http://www.scopus.com/inward/record.url?scp=84858076187&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84858076187&partnerID=8YFLogxK

U2 - 10.1038/bmt.2011.102

DO - 10.1038/bmt.2011.102

M3 - Article

VL - 47

SP - 323

EP - 329

JO - Bone Marrow Transplantation

JF - Bone Marrow Transplantation

SN - 0268-3369

IS - 3

ER -