Mesenchymal stromal cells: A novel treatment modality for tissue repair

Maria Ester Bernardo, Franco Locatelli, Willem E. Fibbe

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Mesenchymal stromal cells (MSCs) are multipotent cells that can be isolated from several human tissues and expanded ex vivo for clinical use. MSCs are identified by their adherent properties, immunephenotype, and differentiation potential. MSCs display immunological properties that have been demonstrated both in vitro and in vivo, in animal models and in humans, although the exact mechanisms underlying these effects remain largely unknown. MSCs preferentially home to damaged tissue and secrete paracrine factors with anti-inflammatory properties. The immunomodulatory and reparative and anti-inflammatory properties of MSCs have been tested in a variety of animal models and have been applied in specific clinical settings. Potential clinical applications of MSCs include prevention and treatment of therapy-resistant acute graft-versus-host disease, prevention and treatment of rejection after either hematopoieitc stem cell and solid organ transplantation, tissue repair, and treatment of inborn errors and autoimmune diseases. This review focuses on recent advances that have broadened our understanding of the biological and functional properties of MSCs, which are increasingly attracting the attention of researchers involved in the optimization of approaches for reparative and regenerative cell therapy, as well as in the perspective of modulating immune response against alloantigens or, even, autoantigens.

Original languageEnglish
Title of host publicationAnnals of the New York Academy of Sciences
Pages101-117
Number of pages17
Volume1176
DOIs
Publication statusPublished - 2009

Publication series

NameAnnals of the New York Academy of Sciences
Volume1176
ISSN (Print)00778923
ISSN (Electronic)17496632

Fingerprint

Mesenchymal Stromal Cells
Repair
Tissue
Animals
Anti-Inflammatory Agents
Transplantation (surgical)
Isoantigens
Autoantigens
Stem cells
Grafts
Therapeutics
Animal Models
Organ Transplantation
Graft vs Host Disease
Cell- and Tissue-Based Therapy
Autoimmune Diseases
Stem Cells
Research Personnel

Keywords

  • Autoimmunity
  • Cell therapy
  • Mesenchymal stem cells (MSCs)

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Bernardo, M. E., Locatelli, F., & Fibbe, W. E. (2009). Mesenchymal stromal cells: A novel treatment modality for tissue repair. In Annals of the New York Academy of Sciences (Vol. 1176, pp. 101-117). (Annals of the New York Academy of Sciences; Vol. 1176). https://doi.org/10.1111/j.1749-6632.2009.04607.x

Mesenchymal stromal cells : A novel treatment modality for tissue repair. / Bernardo, Maria Ester; Locatelli, Franco; Fibbe, Willem E.

Annals of the New York Academy of Sciences. Vol. 1176 2009. p. 101-117 (Annals of the New York Academy of Sciences; Vol. 1176).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Bernardo, ME, Locatelli, F & Fibbe, WE 2009, Mesenchymal stromal cells: A novel treatment modality for tissue repair. in Annals of the New York Academy of Sciences. vol. 1176, Annals of the New York Academy of Sciences, vol. 1176, pp. 101-117. https://doi.org/10.1111/j.1749-6632.2009.04607.x
Bernardo ME, Locatelli F, Fibbe WE. Mesenchymal stromal cells: A novel treatment modality for tissue repair. In Annals of the New York Academy of Sciences. Vol. 1176. 2009. p. 101-117. (Annals of the New York Academy of Sciences). https://doi.org/10.1111/j.1749-6632.2009.04607.x
Bernardo, Maria Ester ; Locatelli, Franco ; Fibbe, Willem E. / Mesenchymal stromal cells : A novel treatment modality for tissue repair. Annals of the New York Academy of Sciences. Vol. 1176 2009. pp. 101-117 (Annals of the New York Academy of Sciences).
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